ome transcription factors take a chaperone to the nuclear dance. On page 469, Williams et al. show that STAT5A gets this escort from the ERBB4 receptor tyrosine kinase. ERBB4 becomes an escort upon activation by growth factors such as heregulin (HRG). The activated receptor is known to recruit and phos-phorylate STAT5A and get cleaved, thus releasing ERBB4's intracellular domain (4ICD). William...

Bu çalışmada Simental sığır ırkına ait toplam 202 hayvanda STAT5A-AvaI ve MYF5-TaqI polimorfizmleri ile günlük süt verimi arasındaki ilişkinin araştırılması amaçlanmıştır. PZR tekniği çoğaltılan 215 bç uzunluğundaki STAT5A gen bölgesi AvaI restriksiyon enzimi kesilirken, 512 MYF5 TaqI kesilmiştir. Belirlenen genotipleri laktasyon verimleri ilişki Tek Yönlü Varyans Analizi (ANOVA) değerlendirilm...

Suppressor of cytokine signaling 3 (SOCS3) is a cytokine-induced negative feedback-loop regulator of cytokine signaling. More and more evidence has proved it to be an inhibitor of signal transducers and activators of transcription 5 (STAT5). Here, we used dairy cow mammary epithelial cells (DCMECs) to analyze the function of SOCS3 and the interaction between SOCS3 and STAT5a. The expression of ...

BACKGROUND Transcription factor Stat5a/b is highly critical for the viability of human prostate cancer cells in vitro and for prostate tumor growth in vivo. Stat5 is constitutively active in clinical prostate cancers but not in the normal human prostate epithelium. Moreover, Stat5a/b activation in prostate cancer is associated with high histological grade of prostate cancer. However, the molecu...

ome transcription factors take a chaperone to the nuclear dance. On page 469, Williams et al. show that STAT5A gets this escort from the ERBB4 receptor tyrosine kinase. ERBB4 becomes an escort upon activation by growth factors such as heregulin (HRG). The activated receptor is known to recruit and phos-phorylate STAT5A and get cleaved, thus releasing ERBB4's intracellular domain (4ICD). William...

ome transcription factors take a chaperone to the nuclear dance. On page 469, Williams et al. show that STAT5A gets this escort from the ERBB4 receptor tyrosine kinase. ERBB4 becomes an escort upon activation by growth factors such as heregulin (HRG). The activated receptor is known to recruit and phos-phorylate STAT5A and get cleaved, thus releasing ERBB4's intracellular domain (4ICD). William...

STAT protein species are well-known as transcription factors that regulate nuclear gene expression. Recent novel lines of research suggest new non-genomic functions of STAT5A/B and STAT6. It was discovered in human pulmonary arterial endothelial cells that STAT5A, including STAT5A-GFP, constitutively associated with the Golgi apparatus, and both STAT5A and B with the endoplasmic reticulum. Acut...

We report unexpected nongenomic functions of signal transducer and activator of transcription (STAT) 5 species in the cytoplasm aimed at preserving the structure and function of the Golgi apparatus and rough endoplasmic reticulum (ER) in vascular cells. Immunoimaging and green fluorescent protein-tagged-STAT5a protein localization studies showed the constitutive association of nonphosphorylated...

Stat5b gene disruption leads to an apparent growth hormone (GH) pulse insensitivity associated with loss of male-characteristic body growth rates and male-specific liver gene expression (Udy, G. B., Towers, R. P., Snell, R. G., Wilkins, R. J., Park, S. H., Ram, P. A., Waxman, D. J., and Davey, H. W. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 7239-7244). In the present study, disruption of the m...

The two transcription factors STAT5A and STAT5B are central signaling molecules in leukemias driven by Abelson fusion tyrosine kinases and they fulfill all criteria of drug targets. STAT5A and STAT5B display unique nuclear shuttling mechanisms and they have a key role in resistance of leukemic cells against treatment with tyrosine kinase inhibitors (TKI). Moreover, STAT5A and STAT5B promote sur...