Methoxyamine (MX) has been shown to potentiate the antitumor effect of temozolomide (TMZ) in human tumor xenograft models. This potentiation is due to the reactivity of MX with apurinic/pyrimidinic (AP) sites in DNA, which are formed following DNA glycosylase removal of TMZ-induced methyl-purine adducts. MX-bound AP sites cannot be further processed by base excision repair (BER), resulting in c...

MX-2401 is an expanded-spectrum lipopeptide antibiotic selective for Gram-positive bacteria that is a semisynthetic analog of the naturally occurring lipopeptide amphomycin. It was active against Enterococcus spp., including vancomycin-sensitive Enterococcus (VSE), vanA-, vanB-, and vanC-positive vancomycin-resistant Enterococcus (VRE), linezolid- and quinupristin-dalfopristin-resistant isolate...

The Mx (myxovirus resistance) gene codes for a protein with antiviral activity. Non-synonymous G/A polymorphism at position 2032 of chicken Mx cDNA results in a change at amino acid 631 of the Mx protein. This mutation has been shown to affect the antiviral activity of the Mx molecule, although recent studies have not confirmed this effect in response to some influenza strains. Nevertheless, th...

The WSMO-MX service matchmaker applies different matching filters to retrieve Semantic Web services written in a dialect of the prominent service description language WSML-Rule. For this purpose, WSMO-MX recursively computes logicbased and syntactic similarity-based matching degrees and returns a ranked set of services that are semantically relevant to a given query. The matching filters perfor...

There is limited information on the prevalence of the potent mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in U.S. water supplies. We measured MX concentrations and mutagenic activity in tap water samples from 36 surface water systems throughout Massachusetts. We found MX levels much higher (up to 80 ng/L) than previously reported in the United States. We also evaluated the ...

, Abstract We study an eMcient iterative algorithm fbr computing the stationary distributions ih MX/G/IZN queues with arbitrary state-dependent arrivals, that is, ., MX(k)/C/1/N queues. MX(k)/G/1/N queues include the well studied specidl cases, such as PBAS (partially batch acceptance strategy) At(,X/G/1/N queues and tt WBAS (whole batch acceptance strategy) MX/C/1/N queues. We only require the...

We propose a novel approach in the assessment of random risk variable X by introducing magnitude-propensity measures (mX, pX). This bivariate measure intends to account for dual aspect risk, where magnitudes x tell how high are losses incurred, whereas probabilities P(X = x) reveal often one has expect suffer such losses. The basic idea is simultaneously quantify both severity mX and propensity...

BACKGROUND Sansanmycins are uridyl peptide antibiotics (UPAs), which are inhibitors of translocase I (MraY) and block the bacterial cell wall biosynthesis. They have good antibacterial activity against Pseudomonas aeruginosa and Mycobacterium tuberculosis strains. The biosynthetic gene cluster of sansanmycins has been characterized and the main biosynthetic pathway elucidated according to that ...

objective: iododeoxyuridine-induced radiosensitivityi (iudr) is a halogenated thymidine analogue recognized to be effective in vitro and in vivo radiosensitizer in human cancers. it is reported that methoxyamine (mx) potentiates dna damages in cancer cells with blocking the repair pathway of iudr damages. but studies, entirely, are restricted on monolayer culture cells from human colon cancer c...

BACKGROUND Myxovirus resistance (Mx) proteins are crucial effectors of the innate antiviral response against a wide range of viruses, mediated by the type I interferon (IFN-I) signaling pathway. However, the antiviral activity of Mx proteins is diverse and complicated in different species. METHODOLOGY/PRINCIPAL FINDINGS In the current study, two novel Mx genes (CiMx1 and CiMx3) were identifie...