Background: One of the most important metabolic factors affecting the reproductive activity is insulin-like growth factor-I (IGFI) concentration changes after calving. Recently, Maj et al. (2008) discovered a significant association between the IGF-I genotypes based on the 5'-untranslatedregion (5'-UTR) of IGF-I gene and the IGF-I blood level. The objective of this study is to investi...

ABSTRACT Introduction Skeletal muscle injuries account for 10% to 50% of treadmill sports injuries. Insulin-like growth factor (IGF) is a family polypeptides with both insulin-like anabolic and growth-promoting effects. Sports play vital role in the recovery skeletal Objective The paper analyzes ability 1 (IGF-1) repair injury caused by exercise. Method We injected drugs under wound after exerc...

The insulin-like growth factor-1 receptor (IGF-1R) is a transmembrane receptor with tyrosine kinase activity. The receptor plays a critical role in cancer. Using monoclonal antibodies (MAbs) against the IGF-1R, typically blocks ligand binding and enhances down-regulation of the cell-surface IGF-1R. Some MAbs such as cixutumumab are under clinical trial investigation. Targeting multiple distinct...

Persistent hyperglycemia resulting from diabetes mellitus causes microvascular lesions and long-term diabetic complications, such as nephropathy. The aim of the study was to analyze levels insulin-like growth factors (IGFs), their carrier proteins (IGFBP), markers kidney tissue damage (IL-18, L-FABP, cystatin C, NGAL, KIM-1) in male rats with mellitus, tumor growth, combination. Materials metho...

Background: Liver cirrhosis is one of the most significant causes death in many regions worldwide. This study aimed to assess correlation hemostatic and endocrine parameters with Child-Turcotte-Pugh (CTP) scoring patients non-alcoholic liver cirrhosis. Materials Methods: included 59 monitored for a gastroenterology clinic from January 2018 February 2019. The subjects were grouped according CTP ...

Introduction  Insulin-like growth factor I (IGF-I) which is produced in abundance in the normal adult liver, is deeply involved in hepatocyte survival, growth, and differentiation during liver development. IGF-I plays the roles via the receptor (IGF-IR) signaling pathway. IGF-IR unlike IGF-I is expressed strongly in the developing liver, but much more weakly in adults. Objective:  We hypothesi...