Gene expression variation between species is a major contributor to phenotypic diversity, yet the underlying flexibility of transcriptional regulatory networks remains largely unexplored. Transcription of the ribosomal regulon is a critical task for all cells; in S. cerevisiae the transcription factors Rap1, Fhl1, Ifh1, and Hmo1 form a multi-subunit complex that controls ribosomal gene expressi...

The identities of proteins that show disuse-related changes in the content of oxidative modification are unknown. Furthermore, it is unknown whether the global accumulation of oxidized proteins is greater in aged animals with muscle disuse. The purposes of this study are 1) to identify the exact proteins that show disuse-related changes in oxidation levels and 2) to test the hypothesis that the...

Mutations in genes encoding a key component of cytotoxic granules, or the machinery for their release, underlie the systemic hyperiflammatory symptoms of familial hemophagocytic lymphohistiocytosis (FHL), a typically pediatric onset autosomal recessive disorder with five known genetic subtypes (FHL1 5). FHL1 mutations have been mapped to chromosome 9, while the respective genes mutated in FHL2 ...

The name Teyjus stands ambiguously for a project and a family of systems that are about providing an efficient and robust implementation of the language λProlog. As a project, Teyjus has spanned a period of over fifteen years, involving people from Duke University, SUNY Buffalo, the University of Chicago and the University of Minnesota. As a system, Teyjus has seen two incarnations. Its first v...

The name Teyjus stands ambiguously for a project and a family of systems that are about providing an efficient and robust implementation of the language λProlog. As a project, Teyjus has spanned a period of over fifteen years, involving people from Duke University, SUNY Buffalo, the University of Chicago and the University of Minnesota. As a system, Teyjus has seen two incarnations. Its first v...