A hypomorphic electrophoretic variant of C3 with the mobility of C3 F was found in the serum of a healthy man, his mother, and one of his two sons. Serum C3 concentrations were normal in these subjects as were hemolytic complement levels. Metabolic studies with radiolabeled purified C3 FF and C3 SS in the propositus suggested, but did not prove, that the variant C3 F gene was hyposynthetic. The...

A ghost in the stable module category of a group G is a map between representations of G that is invisible to Tate cohomology. We show that the only non-trivial finite p-groups whose stable module categories have no non-trivial ghosts are the cyclic groups C2 and C3. We compare this to the situation in the derived category of a commutative ring. We also determine for which groups G the second p...

A graph is (k1, k2)-colorable if its vertex set can be partitioned into a graph with maximum degree at most k1 and and a graph with maximum degree at most k2. We show that every (C3, C4, C6)-free planar graph is (0, 6)-colorable. We also show that deciding whether a (C3, C4, C6)-free planar graph is (0, 3)-colorable is NP-complete.

C3 glomerulopathy is a recently described form of CKD. C3GN is a subtype of C3 glomerulopathy characterized by predominant C3 deposits in the glomeruli and is commonly the result of acquired or genetic abnormalities in the alternative pathway (AP) of the complement system. We identified and characterized the first mutation of the C3 gene (p. I734T) in two related individuals diagnosed with C3GN...

Mice bearing a disrupted C3 locus (C3-/-) have an impaired Ab response to T-dependent Ags (bacteriophage phiX 174 and nuclear protein-keyhole limpet hemocyanin) characterized by a reduction in number and size of germinal centers and impaired retention of Ag by follicular dendritic cells. To test the importance of C3 synthesized locally within the lymphoid compartment during an immune response t...

Clostridium botulinum C3 exoenzyme (C3) selectively inactivates RhoA/B/C GTPases by ADP-ribosylation. Based on this substrate specificity C3 is a well-established tool in cell biology. C3 is taken up by eukaryotic cells although lacking an uptake and translocation domain. Based on different approaches vimentin was identified as membranous C3-interaction partner by mass spectrometry. Vimentin in...

The activity in human serum which is responsible for conversion of C3 proactivator (C3PA) to C3 activator was shown to reside in a 3S alpha-globulin. The factor, called C3PA convertase (C3PAse), was obtained in partially purified form. For conversion of C3PA, C3PAse required participation of metal ions and of a C3 fragment, which in physicochemical and antigenic properties resembled C3b. Isolat...