نتایج جستجو برای: چارچوب gof
تعداد نتایج: 18532 فیلتر نتایج به سال:
The central ethical claim of Casadevall et al. in “An Epistemological Perspective on the Value of Gain-of-Function Experiments Involving Pathogens with Pandemic Potential” (1) is that, when conducting risk-benefit analyses on studies that use gain-offunction (GOF) methods to create potential pandemic pathogens (PPP), we ought to explicitly account for the value of the “epistemic gains” of the e...
Staphylococcus aureus is bacteria identified in the root canal of infected teeth by 20%, resistant and isolated from secondary treatment. NaOCl 2.5%has toxic properties causes irritation when pushed into periapical tissue. Green okra fruit (GOF) extract has antibacterial metabolite compound i.e.flavonoids, alkaloids, saponins, tannins terpenoids. This research was carried out to determine inhib...
One of the most prevalent and traditional uses statistics in hydrology is flood frequency analysis. The can occur practically everywhere considered leading cause natural disaster death worldwide. This study aims to apply analysis Kelantan streamflow site identify optimal distribution that best fits data from goodness-of-fit test (GOF). Five distributions were applied this study; namely lognorma...
In Candida glabrata, the transcription factor CgPdr1 is involved in resistance to azole antifungals via upregulation of ATP binding cassette (ABC)-transporter genes including at least CgCDR1, CgCDR2 and CgSNQ2. A high diversity of GOF (gain-of-function) mutations in CgPDR1 exists for the upregulation of ABC-transporters. These mutations enhance C. glabrata virulence in animal models, thus indic...
رادیوی شناختی قادر است از طریق حسگری طیفی، حضور یا عدم حضور کاربران اصلی باند فرکانسی مورد نظر را آشکارسازی نموده و با توجه به اطلاعات حاصله، به صورت فرصت طلبانه از طیف بهره برداری کند. مهم ترین چالش در این زمینه، احتمال عدم آشکارسازی صحیح حضور کاربران اصلی طیف می باشد که ممکن است باعث اختلالات جبران ناپذیری در شبکه شود. روش های مختلفی برای حسگری طیفی پیشنهاد شده است که بیشتر پژوهش های انجام شد...
Heterozygous gain-of-function (GOF) mutations of STAT1 are responsible for chronic mucocutaneous candidiasis disease (CMCD), one of the primary immunodeficiency diseases characterized by susceptibility to mucocutaneous Candida infection. To date, 30 aa changes have been reported: 21 in the coiled-coil domain and 9 in the DNA-binding domain. In this study, we report two novel STAT1 GOF mutations...
The mucolipin TRP (TRPML) proteins are a family of endolysosomal cation channels with genetically established importance in humans and rodent. Mutations of human TRPML1 cause type IV mucolipidosis, a devastating pediatric neurodegenerative disease. Our recent electrophysiological studies revealed that, although a TRPML1-mediated current can only be recorded in late endosome and lysosome (LEL) u...
BACKGROUND Chronic mucocutaneous candidiasis disease (CMCD) may result from various inborn errors of interleukin (IL)-17-mediated immunity. Twelve of the 13 causal mutations described to date affect the coiled-coil domain (CCD) of STAT1. Several mutations, including R274W in particular, are recurrent, but the underlying mechanism is unclear. OBJECTIVE To investigate and describe nine patients...
Since the spring of 2014, there has been a vibrant debate in the scientific community about the benefits and risks of so-called gain-of-function (GOF) studies involving pathogens with pandemic potential and particularly highly pathogenic avian influenza virus (HPAIV) (1). In October 2014, the U.S. government announced a pause for research involving GOF experiments with three respiratory viruses...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید