This study investigates the effect of carbide particle size on the microstructure, mechanical properties, and abrasive wear resistance of WC-17%Co HVOF-sprayed coatings. The characteristics of WC-1, WC-2, and WC-3 coatings with carbide sizes of 1 µm, 0.9 µm, and 0.5 µm, respectively, were also investigated. WC-1 coating experienced the maximum carbon loss of 42%, while WC-2 and WC-3 coatings un...

In the frq-wc-based circadian feedback loops of Neurospora, two PAS domain-containing transcription factors, WHITE COLLAR-1 (WC-1) and WC-2, form heterodimeric complexes that activate the transcription of frequency (frq). FRQ serves two roles in these feedback loops: repressing its own transcription by interacting with the WC complex and positively upregulating the levels of WC-1 and WC-2 prote...

The Ugi four-component reaction (U-4CR) with N-hydroxyimides as a novel carboxylic acid isostere has been reported. This reaction provides straightforward access to α-hydrazino amides. A broad range of aldehydes, amines, isocyanides and N-hydroxyimides were employed to give products in moderate to high yields. This reaction displays N-N bond formation by cyclic imide migration in the Ugi reacti...

Sterols which have been identified in a transplantable preputial gland tumor are lanosterol, 24,25-dihydrolanosterol, 4cr-methylAs-cholestenol, A’-cholestenol, 7-dehydrocholesterol, and cholesterol (preceding paper (2)). Arranged in the above sequence, they suggest a possible pathway for the conversion of lanosterol to cholesterol. The studies presented in this report of acetate incorporation i...

A convenient base-mediated two-step synthesis of cotinine analogs and a one-pot base-free synthesis of iso-cotinine derivatives featuring an Ugi-4CR/cyclization protocol are reported. These approaches exploit the reactivity of the peptidyl position present in the Ugi adducts, allowing the facile construction of the γ-lactam core, as well as the introduction of a N-substituted methyl group into ...

The basic algorithm is derived from the weak-commitment algorithm (WC) of Yokoo [17], which has been shown to outperform breakout and min-conflict backtracking on certain classes of problems. Weakcommitment search is that part of WC which results from removing the learning mechanism; this will be called WC-NL. WC-NL is coupled with learning-by-merging to form the new algorithm WC-NG. Experiment...

Interlocked feedback loops may represent a common feature among the regulatory systems controlling circadian rhythms. The Neurospora circadian feedback loops involve white collar-1 (wc-1), wc-2, and frequency (frq) genes. We show that WC-1 and WC-2 proteins activate the transcription of frq gene, whereas FRQ protein plays dual roles: repressing its own transcription, probably by interacting wit...