The survival protein E (SurE) family was discovered by its correlation to stationary phase survival of Escherichia coli and various repair proteins involved in sustaining this and other stress-response phenotypes. In order to better understand this ancient and well-conserved protein family, we have determined the 2.0A resolution crystal structure of SurEalpha from the hyperthermophilic crenarch...

BACKGROUND Currently, large prostate size (>80 mL) of benign prostatic hyperplasia (BPH) still pose technical challenges for surgical treatment. This prospective study was designed to explore the safety and efficacy of prostatic arterial embolization (PAE) as an alternative treatment for patients with lower urinary tract symptoms (LUTS) due to largeBPH. METHODS A total of 117 patients with pr...

INTRODUCTION On account of the multifaceted structural damage induced by prenatal alcohol exposure (PAE), MR image registration problems have been a roadblock in the detailed analysis of images from this population. The recently introduced DARTEL (diffeomorphic anatomical registration through exponentiated lie algebra) algorithm [1] is thought to improve inter-subject functional image registrat...

Hyperoxia prolongs the postantibiotic effect (PAE) of the aminoglycoside tobramycin in Pseudomonas aeruginosa. We tested the hypothesis that the PAE is prolonged because hyperoxia increases free radical flux while tobramycin inhibits the induction of antioxidant defenses. Exposure of P. aeruginosa to hyperoxia (100% O2) for 1 h increased superoxide dismutase, catalase, and glutathione levels. I...

OBJECTIVE The aim of this study was to evaluate indications, efficacy, and complications associated with pelvic arterial embolization (PAE) for postpartum hemorrhage (PPH). METHODS We retrospectively reviewed the medical records of 117 consecutive patients who underwent PAE for PPH between January 2006 and June 2013. RESULTS In our single-center study, 117 women underwent PAE to control PPH...

STUDY OBJECTIVES To evaluate the effects of nonselective endothelin (ET)-receptor antagonism on the hemodynamic changes and serum thromboxane (TX)-A(2) levels after a massive pulmonary air embolism (PAE) in dogs. DESIGN Prospective trial. SETTING University laboratory. INTERVENTIONS Anesthetized mongrel dogs (ET-receptor antagonist group; n = 6) received a bolus injection of 1 mg of the n...

The natural expression of tissue-specific genes in the thymus, e.g., insulin, is critical for self-tolerance. The transcription of tissue-specific genes is ascribed to peripheral Ag-expressing (PAE) cells, which discordant studies identified as thymic epithelial cells (TEC) or CD11c+ dendritic cells (DC). We hypothesized that, consistent with APC function, PAE-DC should constitutively display m...