نتایج جستجو برای: پروتئین asxl1
تعداد نتایج: 18286 فیلتر نتایج به سال:
Chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) are rare entities grouped into the World Health Organisation (WHO) categories myeloproliferative and myelodysplastic/myeloproliferative neoplasms (MPN and MDS/MPN overlap), respectively. According to the WHO 2008 classification, both entities are characterized by leukocytosis and a hypercellular bone marrow, predom...
Although tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of chronic myeloid leukemia (CML), the ability of TKIs to eradicate CML remains uncertain and patients must continue TKI therapy for indefinite periods. In this study, we performed whole-exome sequencing to identify somatic mutations in 24 patients with newly diagnosed chronic phase CML who were registered in t...
The karyotype is so far the most important prognostic parameter in acute myeloid leukemia (AML). Molecular mutations have been analyzed to subdivide AML with normal karyotype into prognostic subsets. The aim of this study was to develop a prognostic model for the entire AML cohort solely based on molecular markers. One thousand patients with cytogenetic data were investigated for the following ...
Mutations in genes of the splicing machinery have been described recently in myelodysplastic syndromes (MDS). In the present study, we examined a cohort of 193 MDS patients for mutations in SRSF2, U2AF1 (synonym U2AF35), ZRSR2, and, as described previously, SF3B1, in the context of other molecular markers, including mutations in ASXL1, RUNX1, NRAS, TP53, IDH1, IDH2, NPM1, and DNMT3A. Mutations ...
Primary myelofibrosis (PMF), a BCR-ABL negative myeloproliferative neoplasm, is heterogeneous clinical and genetic disorder with poor prognosis. We aimed to study the mutational profile of driver genes (JAK2, CALR, MPL) high-molecular-risk (HMR) (ASXL1, EZH2, IDH1/2, SRSF2) their prognostic impact in 65 Argentine patients PMF. Mutually exclusive mutations were identified 88% cases HMR detected ...
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