5'-methylthioadenosine (MTA) is a nucleoside generated from S-adenosylmethionine (AdoMet) during polyamine synthesis. Recent evidence indicates that AdoMet modulates in vivo the production of inflammatory mediators. We have evaluated the anti-inflammatory properties of MTA in bacterial lipopolysaccharide (LPS) challenged mice, murine macrophage RAW 264.7 cells, and isolated rat hepatocytes trea...

OBJECTIVES The aim of the present study was to conduct a clinical and radiographic long-term evaluation of pulpotomy in temporary molars performed with Grey and White Mineral Trioxide Aggregate (MTA) and compare the results of Grey and White MTA pulpotomies in a sample of 233 primary molars with a maximum follow-up period of 84 months. METHODS The sample was selected from patients treated at ...

Purpose. To compare the biocompatibility and antimicrobial effectiveness of the new Fast-Set MTA (FS-MTA) with ProRoot MTA (RS-MTA). Methods. The agar overlay method with neutral red dye was used. L929 mouse fibroblast cells were cultured. The liquid and oil extracts and solid test material were placed on the agar overlay, four samples for each material. Phenol was used as the positive control ...

The purpose of this investigation was to study, in vitro, the antifungal effect of mineral trioxide aggregate (MTA) using a tube-dilution test. MTA was tested freshly mixed and after 24 h set on Candida albicans. The tested MTA was incubated with C. albicans for 1 h, 24 h, and 3 days. Results showed that the freshly mixed MTA was effective in killing the tested fungi after 1 day of contact, whe...

Two cases are reported in which incomplete placement of 4 mm mineral trioxide aggregate (MTA) plug was performed unintentionally at the apical third of permanent immature teeth with open apex and apical periodontitis. As confirmed radiographically, there were gaps between MTA and dentinal walls along the MTA-dentin interface. After setting of MTA was confirmed, endodontic treatment was complete...

AIM To compare the percentage of apoptotic cells and the cell cycle profile of fibroblasts and macrophages exposed to either ProRoot mineral trioxide aggregate (MTA) mixed with chlorhexidine (CHX), or exposed to ProRoot MTA mixed with sterile water. METHODOLOGY Mouse gingival fibroblasts or mouse macrophages were seeded in six-well plates and allowed to attach overnight. Freshly mixed or set ...

This study investigated the ability of One-Up Bond alone and mineral trioxide aggregate (MTA), with and without a secondary seal of One-Up Bond or SuperEBA to seal saucer-shaped perforation defects in human molars. Cusps were removed, roots were amputated, and endodontic therapy completed on 40 extracted teeth. A cylindrical hole was made in each tooth from the furcation area to the chamber, in...

Aim of the Study The aim of this study was to compare and evaluate the sealing ability of four root end filling materials mineral trioxide aggregate (MTA)-Plus, Biodentine, MTA (MTA Angelus) and glass ionomer cement (GIC) using fluid filtration method. Materials and Methods Forty-four extracted, human single-rooted teeth were collected. The crown of each tooth was decoronated 2 mm above the c...

Introduction: Mineral trioxide aggregate (MTA) as an alternative material to gutta-percha for obturation of root canal in special cases has several drawbacks. The purpose of this study was to compare the apical sealing ability of a new MTA-based sealer versus MTA. Materials and Methods: A total of 36 canals of extracted maxillary central incisors were instrumented and randomly divided into 3...

This study evaluated the influence of the exposure of mineral trioxide aggregate (MTA) - with and without calcium chloride (CaCl2) -to phosphate-buffered saline (PBS) on apical microleakage. Sixty root segments were divided into 4 experimental groups (n=15). Apical cavities were filled with MTA with or without CaCl2, and the root canals dressed with a moistened cotton pellet or PBS: 1) MTA/cott...