BACKGROUND Previous studies in patients with hepatitis C virus (HCV)/HIV coinfection have shown that the presence of GBV-C is associated with significantly less compensated and decompensated cirrhosis, and an improvement in cirrhosis-free survival. OBJECTIVES This study aimed to describe the effect of GBV-C in patients with chronic hepatitis C and HIV coinfection. PATIENTS AND METHODS We re...

1 1. What we know about GB virus type C (Hepatitis G virus) 1 1.1. Molecular structure 1 1.2. History and distribution 1 1.3. Routes of transmission 2 1.4. Prevalence of GBV-C infection 2 1.4.1. Healthy blood donors 2 1.4.2. High risk populations 3 1.5. GBV-C detection methods 3 1.6. Natural history of GBV-C infection in humans 4 1.6.1. GBV-C and HIV co-infection 4 1.6.2. Biological mechanism o...

A molecular epidemiological study was performed to investigate the prevalence of GB virus C/hepatitis G virus (GBV-C/HGV) infection among various populations in Surabaya, Indonesia. The prevalence of GBV-C/HGV RNA, determined by reverse transcription-PCR for a portion of the NS3 region of the viral genome, was 2.7% (4 of 150) among randomly collected blood donor sera, which were all negative fo...

To investigate which subsets of peripheral blood mononuclear cells (PBMCs) are susceptible to infection with hepatitis C virus (HCV) and hepatitis G virus (HGV) or GB virus C (GBV-C), a PCR-based assay using tagged primers in the core region (HCV) and NS3 region (HGV/GBV-C) for the specific detection of negative strand (replicating) viral RNA sequences was developed. In liver biopsy samples bot...

Gender-based violence (GBV) is a global issue that particularly prevalent among women of color. Many providers in GBV-based organizations are also survivors GBV, which affects the way these lead social service and justice organizations. Yet, many institutions at intersections GBV fail to address impact has on mind, body, spirit who work there. Using historical trauma as lens, this qualitative s...

GB vims-C (GBV-C)仇epatitis G vims (HGV) is a positive, single-strand RNA virus that has been classified in the family Flaviviridae. Interestlngly, GBVIC/HGV appears to have a truncated or absent core protein at the amino teminus of the polyprotein. GBV-C/HGV is transmitted parenterally and probably sexually. Most GBV-C作iGV infections appear to be asymptomatiC, persistent, and no correlation bet...

AIM The aim of this study was to investigate the prevalence of GBV-C among Iranian HBV positive patients using PCR-RFLP technique. BACKGROUND GBV-C was a member of flaviviridae family and recently propose to classify as members of a fourth genus in this family, named Pegivirus and suggest that at least one quarter of the world's population has been infected with this virus. GBV-C can be trans...

The aim of the present study was to evaluate the prevalence of HEV, TTV and GBV-C/GBV-C/HGV in patients with acute viral hepatitis A, B and non-A-C. We evaluated sera of 94 patients from a sentinel program who had acute hepatitis A (N = 40), B (N = 42) and non-A-C (N = 12); 71 blood donors served as controls. IgM and anti-HEV IgG antibodies were detected by enzyme immunoassay using commercial k...

A strategy for antiviral drug discovery is the elucidation and imitation of viral interference mechanisms. HIV-1 patients benefit from a coinfection with GB Virus C (GBV-C), since HIV-positive individuals with long-term GBV-C viraemia show better survival rates than HIV-1 patients without persisting GBV-C. A direct influence of GBV-C on HIV-1 replication has been shown in coinfection experiment...

GB virus C (GBV-C) is prevalent globally and particularly among individuals at risk of parental exposures. Based on genetic diversity, this virus is now classified into six genotypes and many subtypes with distinct geographical distribution. In this study, 120 Injecting Drug Users (IDUs) were recruited from Yunnan province, China. Among them, 43 (35.8%) were positive for GBV-C RNA, 70 (58.3%) a...