It has been reported that theophylline is primarily metabolized via hepatic CYP1A1/2, 2B1/2, and 3A1/2, and 1,3-dimethyluric acid (1,3-DMU) is primarily formed via CYP1A1/2 in rats. Compared with control rats, the expression of CYP1A subfamily, 2B1/2, and 3A subfamily significantly decreased 24 h (24-h KPLPS rats) after intravenous administration of lipopolysaccharide derived from Klebsiella pn...

Data envelopment analysis (DEA) is a useful tool based on which inefficient decision-making units (DMUs) can perform a benchmarking process to improve their performance. However, several practical problems need to be addressed in benchmark target selection. One issue discussed in this research is that it might not be feasible for an inefficient DMU to achieve its target’s efficiency in a single...

It has been reported that theophylline is primarily metabolized via hepatic CYP1A1/2, 2B1/2, and 3A1/2, and 1,3-dimethyluric acid (1,3-DMU) is primarily formed via CYP1A1/2 in rats. Compared with control rats, the expression of CYP1A subfamily, 2B1/2, and 3A subfamily significantly decreased 24 h (24-h KPLPS rats) after intravenous administration of lipopolysaccharide derived from Klebsiella pn...

Rapid technological progress is responsible for continously changing IT-infrastuctures. This makes the introduction of new long term IT-solutions a difficult task. To handle software requirements for a new IT-tool we chose use cases, a software engineering technique for requirements documentation, and adopted it to our specific needs. Use cases have a number of well known weaknesses like featur...

We evaluate, by means of mathematical programming formulations, the relative technical and scale efficiencies of decision making units (DMUs) when some of the inputs or outputs are exogenously fixed and beyond the discretionary control of DMU managers. This approach further develops the work on efficiency evaluation and on estimation of efficient production frontiers known as data envelopment a...