Activator of G-protein signaling 3 (AGS3) and LGN have a similar domain structure and contain four G-protein regulatory motifs that serve as anchors for the binding of the GDP-bound conformation of specific G-protein alpha subunits. As an initial approach to define further the different functional roles of AGS3 and LGN, we determined their expression profile and subcellular distribution. AGS3- ...

We provide efficient parallel algorithms for the minimum separation, offset range, and optimal offset problems for single-layer channel routing. We consider all the variations of these problems that are known to have lineartime sequential solutions rather than limiting attention to the “river-routing” context, where single-sided connections are disallowed. For the minimum separation problem, we...

Consider laying out a fixed-topology tree of N nodes into external memory with block size B so as to minimize the worst-case number of block memory transfers required to traverse a path from the root to a node of depth D. We prove that the optimal number of memory transfers is Θ   D lg(1+B) when D = O(lgN) lgN lg ( 1+ lg N D ) when D = Ω(lgN) and D = O(B lgN) D B when D ...

PURPOSE To investigate lateral geniculate nucleus (LGN) volume of primary open-angle glaucoma (POAG) patients compared with age- and sex-matched controls using ultra-high field 7.0-T magnetic resonance imaging (MRI). METHODS The study included 18 patients with POAG and 18 age- and sex-matched healthy volunteers. All subjects underwent imaging on a high-resolution 7.0-T MRI system. Bilateral L...

High-order statistics of neural responses allow one to gain insight into neural function that may not be evident from firing rate alone. In this study, we compare the precision, reliability, and information content of spike trains from Xand Y-cells in the lateral geniculate nucleus (LGN) and layer IV simple cells of area 17 in the cat. Using a stochastic, contrast-modulated Gabor patch, we foun...

The spatial structure of the receptive field (RF) of cat lateral geniculate nucleus (LGN) neurons is significantly elliptical, which may provide a basis for the orientation tuning of LGN neurons, especially at high spatial frequency stimuli. However, the input mechanisms generating this elliptical RF structure are poorly defined. We therefore compared the spatiotemporal RF structures of pairs o...

Fundamental to neuroscience is the understanding of how the language of neurons relates to behavior. In the lateral geniculate nucleus (LGN), cells show distinct properties such as selectivity for particular wavelengths, increments or decrements in contrast, or preference for fine detail versus rapid motion. No studies, however, have measured how LGN cells respond when an animal is challenged t...

During the first postnatal month in the ferret (Mustela putorius furo), the projections from the retina to the lateral geniculate nucleus (LGN) become segregated into eye-specific layers and ON and OFF sublayers, a process that is thought to depend in part on neuronal activity. Remarkably, virtually nothing is known about the physiological features of LGN neurons during this period. We have rec...