AIMS Thrombolytic therapy restores coronary patency in patients with acute myocardial infarction, although normal perfusion (TIMI 3 flow) is not achieved in all patients. In an attempt to improve TIMI 3 flow, a combination of full-dose streptokinase, aspirin and escalating dosages of a platelet glycoprotein IIb/IIIa receptor blocker, eptifibatide, vs placebo were tested. METHODS AND RESULTS A...

BACKGROUND Although improved epicardial blood flow (as assessed with either TIMI flow grades or TIMI frame count) has been related to reduced mortality after administration of thrombolytic drugs, the relationship of myocardial perfusion (as assessed on the coronary arteriogram) to mortality has not been examined. METHODS AND RESULTS A new, simple angiographic method, the TIMI myocardial perfu...

OBJECTIVES We analyzed the safety and feasibility of myocardial echocardiography with intracoronary injection of contrast, its effect on left ventricular remodeling and systolic function, and its relationship with angiography and magnetic resonance imaging (MRI) for the evaluation of post-infarction coronary microcirculation. PATIENTS AND METHOD Thirty patients with a first ST-elevation myoca...

OBJECTIVE To investigate which risk score (TIMI score or HEART score) identifies the largest population of low-risk patients at the emergency department (ED). Furthermore, we retrospectively calculated the corresponding expected decrease in medical consumption if these patients would have been discharged from the ED. METHODS We performed analyses in two hospitals of the multicentre prospectiv...

BACKGROUND AND PURPOSE Although the combined end point of partial and complete recanalization is a well-established predictor of good outcome following acute stroke intervention, few investigations have evaluated the effect of the degree of recanalization. We hypothesized that greater degrees of recanalization would be associated with a higher likelihood of favorable functional outcomes. MATE...

OBJECTIVE Patent perforators, noninvasively imaged by transthoracic color-Doppler echocardiography, may reflect adequate reperfusion in anterior myocardial infarction (MI). BACKGROUND The Thrombolysis In Myocardial Infarction (TIMI) classification may not fully reflect adequate myocardial reperfusion in MI. METHODS We studied 61 patients with anterior MI undergoing thrombolysis (n = 28), pr...

به کمک شبیه ­سازی دینامیک مولکولی می ­توان تحلیل کوتاه مدت در مقیاس زمانی چند ده پیکوثانیه ­ای را برای مواد آسیب دیده­ی تابشی مورد مطالعه قرار داد. بر همین مبنا این ­سازی، تعداد تعادلی عیوب نقطه بین ­نشین و تهی ­جای مختصات مکانی آن­ها آهن- آلفا دست آورده شد. سپس با استفاده از نتایج حاصل شده، مونت کارلوی جنبشی شیء منظور بررسی تأثیر بازپخت آلفای انجام نشان دادند که یکنواخت دیده­ ی تنها خوشه جای ب...

The left internal mammary artery (LIMA) is the most commonly used arterial graft for coronary artery bypass graft (CABG) surgery, and occluding the LIMA side branches during surgery is important to avoid myocardial ischaemia afterwards. In this study we investigated the incidence of patent LIMA graft side branches in our coronary angiography series, and compared LIMA flow rate changes by means ...