Optic cups are a structural feature of diverse eyes, from simple pit eyes to camera eyes of vertebrates and cephalopods. We used the planarian prototypic eye as a model to study the genetic control of optic cup formation and regeneration. We identified two genes encoding transcription factors, sp6-9 and dlx, that were expressed in the eye specifically in the optic cup and not the photoreceptor ...

Abasic sites are thought to be the most frequently occurring cellular DNA damage and are generated spontaneously or as the result of chemical or radiation damage to DNA. In contrast to the wealth of information that exists on the effects of abasic sites on DNA polymerases, very little is known about how these lesions interact with RNA polymerases. An in vitro transcription system was used to de...

AIM This study is the second report from a single experiment planned to determine if acupuncture at LI4 and SP6, or at the sacral points, could produce any harm in the pregnancy outcome of Wistar rats, as has been hypothesised in traditional knowledge. Here, we observe if these points can be harmful to the health of pregnant Wistar rats. METHODS A total of 48 pregnant Wistar rats were randoml...

Accumulating evidence indicates that oxidative stress plays a critical role in Parkinson's disease (PD). Our previous work has shown that 100 Hz electro-acupuncture (EA) stimulation at ZUSANLI (ST36) and SANYINJIAO (SP6) protects neurons in the substantia nigra pars compacta from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity in male C57BL/6 mice, a model of PD. In the present stu...

BACKGROUND Ki67 labeling index (Ki67 LI), the percentage Ki67 immunoreactive cells, is a measure of tumor proliferation, with important clinical relevance in breast cancer, and it is extremely important to standardize its evaluation. AIM To test the efficacy of computer assisted image analysis (CAIA) applied to completely digitized slides and to assess its feasibility in routine practice and ...

Objective: Hemodialysis is one of the most common treatment methods in kidney patients. To do this, repeated insertion needle into vessel necessary. Patients treated with hemodialysis are exposed to stress and pain caused by perforation their arteriovenous fistula about 300 times a year. More than 1/5 patients express this as unbearable. This study aims evaluate effect acupressure at SP6 ST36 a...

results there were significant differences between the groups in subjective labor pain scores (except vas 4) (p < 0.001). the duration of the phase one (3 cm dilatation to full dilatation) and phase two (full dilatation to birth) in the acupressure group was shorter than the control group (phase one, 225 min and 320 min, respectively; phase two, 15 min and 20 min, respectively; both p < 0.001)....

abstract introduction: primary dysmenorrhea is common in women during reproductive age. objective: this study aimed to determine the effect of acupressure on sixth spleen point (sp6) on relief of primary dysmenorrhea. methods: this study is a clinical trial. students with primary dysmenorrheal living in dormitory were studied during three menstrual cycles. pain intensity was measured on the fir...

BACKGROUND The ratio between amygdala:hippocampal (AH) volume has been associated with multiple psychiatric problems, including anxiety and aggression. Yet, little is known about its biological underpinnings. Here, we used a methylome-wide approach to test (a) whether DNA methylation in early life (birth, age 7) prospectively associates with total AH volume ratio in early adulthood, and (b) whe...