Background It is still unclear which underlying mechanisms are involved in cognitive deficits of psychotic disorders. Pro-cognitive effects of muscarinic M1 receptor agonists suggest alterations in M1 receptor functioning may modulate these symptoms. Post mortem studies in patients with schizophrenia have shown significantly reduced M1 receptor expression rates in the dorsolateral prefrontal co...

An eight-step procedure has been devised for the preparation of homogeneous rabbit reticulocyte IF-M1. Molecular weight determinations based on IF-M1 activity (gel filtration and sucrose density gradient sedimentation) and based on IF-M1 protein (low speed equilibrium sedimentation and sodium dodecyl sulfate gel electrophoresis) indicate that IF-M1 is active as a single polypeptide chain of 65,...

Plasmodium falciparum alanine M1-aminopeptidase (PfA-M1) is a validated target for anti-malarial drug development. Presence of significant similarity between PfA-M1 and human M1-aminopeptidases, particularly within regions of enzyme active site leads to problem of non-specificity and off-target binding for known aminopeptidase inhibitors. Molecular docking based in silico screening approach for...

In this work we compute the Chen–Ruan cohomology of M1,n and M1,n, and its algebraic counterpart: the stringy Chow ring. We suggest a definition for a Chen–Ruan tautological ring in genus 1, which is both a subring of the Chen–Ruan cohomology and of the stringy Chow ring.

Many enveloped viruses encode a matrix protein. In the influenza A virus, the matrix protein M1 polymerizes into a rigid protein layer underneath the viral envelope to help enforce the shape and structural integrity of intact viruses. The influenza virus M1 is also known to mediate virus budding as well as the nuclear export of the viral nucleocapsids and their subsequent packaging into nascent...

The notion of a Laplace ladder for a discrete analogue of the Laplace equation is presented. The adjoint of the discrete Moutard equation and a discrete counterpart of the nonlinear form of Goursat equation are introduced. 1 Notation Value of functions of continuous variables we denote by f(u, v) i.e. f : R ∋ (u, v) 7→ f(u, v) ∈ R while functions of discrete variables by f(m1, m2) i.e. f : Z 2 ...