The aim of this study was to elucidate the characteristics of the transport of lactone and carboxylate forms of SN-38 (SN-38L and SN-38C, respectively), a metabolite of irinotecan hydrochloride (CPT-11), with the human intestinal epithelial cell line, Caco-2. We examined SN-38L and SN-38C uptake from the apical side into Caco-2, and the effects of various compounds on the uptake of SN-38L. SN-3...

We recently reported that Val-SN-38, a novel valine ester prodrug of SN-38, had greatly improved the intracellular accumulation of SN-38 in MCF-7 cell line, probably through enhanced uptake via amino acid transporters. In the present study, the efficacy of Val-SN-38 was further investigated both in vitro and in vivo. It was found that the in vitro cytotoxic effect of Val-SN-38 was similar to th...

Reactions of tin porphyrins with vicinal diols were investigated. Treatment of (TTP)Sn(CCPh)(2) or (TTP)Sn(NHtolyl)(2) with pinacol and 2,3-diphenylbutane-2,3-diol afforded diolato complexes (TTP)Sn[OC(Me)(2)C(Me)(2)O] (1) and (TTP)Sn[OC(Ph)(Me)C(Ph)(Me)O] (2), respectively. Both complexes underwent C-C cleavage reactions to give (TTP)Sn(II) and ketones. Reaction of (TTP)Sn(CCPh)(2) with 1 equi...

OBJECTIVE Schmorl's nodes (SN) are common, but little is known of their relationship with degenerative change and back pain or genetic and environmental factors influencing their expression. We studied healthy female twin volunteers to determine the prevalence and clinical features associated with SN. METHODS Serial sagittal T1- and T2-weighted magnetic resonance images of the lower thoracic ...

VLBI observations at 5 GHz have revealed that supernova 1979C, in the galaxy M100 in the Virgo cluster, has shell structure. The shell is approximately circular with the 50% contour deviating from a circle by an rms of no more than 8% of the radius. The brightness distribution along the ridge may vary. The position of the center of the shell is at R.A.=12 h 22 m 58. s 66758 and decl.=15 • 47 ′ ...

– 2 – Received ; accepted – 3 – ABSTRACT The peculiar type Ia supernova SN 1997br in ESO576-G40 was extensively observed at Beijing Astronomical Observatory (BAO) and Lick Observatory. In this paper, we present and discuss the BV RI photometry and the spectra collected over three months, starting from 9 days before maximum brightness. The light curves of SN 1997br are similar to those of SN 199...

UNLABELLED The aim of this work was to develop a selective method for quantification of Sn(II) and Sn(IV) in dimercaptosuccinic acid (DMSA), ethylcysteinate dimer (ECD), methylenediphosphonic acid (MDP), and pyrophosphate radiopharmaceutical cold kits by differential pulse polarography. METHODS A dripping mercury electrode 150 polarographic/stripping analyzer with a conventional 3-electrode c...

and a method A of summability by means of which a given sequence Su S2, • • • is summable to <r as w—»oo. If a sequence sn is summable A, we say that A {sn} exists and that sn belongs to the summability field of A. If sn is summable A to <r, we say that A {sn} = <r. The method A is regular if A {sn} = lim sn whene...

The action of the symmetric group Sn on the set Parkn of parking functions of size n has received a great deal of attention in algebraic combinatorics. We prove that the action of Sn on Parkn extends to an action of Sn+1. More precisely, we construct a graded Sn+1-module Vn such that the restriction of Vn to Sn is isomorphic to Parkn. We describe the Sn-Frobenius characters of the module Vn in ...

The difference in clinical features and treatment outcomes between localized sinonasal diffuse large B cell lymphoma (SN-DLBCL) and sinonasal extranodal NK/T cell lymphoma (SN-ENKTL) is unclear. Therefore, we analyzed a total of 47 patients with localized SN-DLBCL and 211 patients with localized SN-ENKTL. The age distribution for these two subtypes is very distinct and the B symptoms were more ...