Models transformation is the main key of MDA. The first transformation in MDA is CIM to PIM transformation, the second is PIM to PSM transformation. Most searches deal the transformation from PIM level to PSM level, since there are multiple common points between these two levels. However, the transformation from CIM level to PIM level is rarely addressed in search subjects because they are two ...

Toll-like receptors (TLRs) are important sensors of the innate immune system that recognize conserved structural motifs and activate cells via a downstream signaling cascade. The CD180/MD1 molecular complex is an unusual member of the TLR family, since it lacks the components that are normally required for signal transduction by other TLRs. Therefore the CD180/MD 1 complex has been considered o...

Cellular senescence is a stable state of proliferative arrest that provides a barrier against malignant transformation and contributes to the antitumor activity of certain chemotherapies. Unexpectedly, we found that the expression of proto-oncogene PIM-1, which can promote tumorigenesis, is induced at transcriptional level during senescence. Inhibition of PIM-1 alleviated both replicative and o...

A class of smoothed point interpolation methods (smoothed PIMs) are introduced in this paper, which are derived from the smoothed Galerkin weak-form for variational formulation based on the gradient smoothing techniques [1]. In the scheme of smoothed PIMs, the strain smoothing operation [2] can be applied on different types of smoothing domains which are constructed centring at field nodes, edg...

The incidence and death rate of prostate cancer is increasing rapidly. In addition, the low sensitivity of prostate cancer to chemotherapy makes it difficult to treat this condition. The serine/threonine kinase Pim-1 plays an important role in cell cycle progression and apoptosis inhibition, resulting in prostate tumorigenesis. Therefore, Pim-1 inhibition has been expected to be an attractive t...

BACKGROUND To compare the performance of the Pediatric Risk of Mortality (PRISM), the Pediatric Index of Mortality 2 (PIM 2) and Pediatric Logistic Organ Dysfunction (PELOD) scores at general pediatric intensive care unit in a developing country setting, investigating the relation between observed and predicted mortality. METHOD A contemporary cohort study was undertaken at Pediatric Intensiv...

BACKGROUND Personal Information Management (PIM) refers to the tools and activities to save and retrieve personal information for future uses. This study examined the PIM activities of faculty members of Iran University of Medical Sciences (IUMS) regarding their preferred PIM tools and four aspects of acquiring, organizing, storing and retrieving personal information. METHODS The qualitative ...

All mycobacterial species, including pathogenic Mycobacterium tuberculosis, synthesize an abundant class of phosphatidylinositol mannosides (PIMs) that are essential for normal growth and viability. These glycolipids are important cell-wall and/or plasma-membrane components in their own right and can also be hyperglycosylated to form other wall components, such as lipomannan and lipoarabinomann...

Processing-In-Memory (PIM) systems avoid the von-Neumann bottleneck in conventional machines by integrating high-density DRAM and CMOS logic on the same chip. Parallel systems based on this technology are expected to provide higher scalability, adaptability, robustness, fault tolerance, and lower power consumption than current MPPs or commodity clusters. Most current PIM-related research deals ...

Use practices in personal information management (PIM) evolve continually. The data from our two studies, a survey study (n=61) on to-do use practices and a diary/interview study (n=11) on smartphone use in PIM, suggests that electronic PIM has finally reached paper-based PIM in popularity. Mobile phones and their development have been integral to this development: Better input possibilities an...