In this paper, we show how an extended Guided Local Search (GLS) can be applied to the Quadratic Assignment Problem (QAP). GLS is a general, penalty-based meta-heuristic, which sits on top of local search algorithms, to help guide them out of local minima. We present empirical results of applying several extended versions of GLS to the QAP, and show that these extensions can improve the range o...

INTRODUCTION AND OBJECTIVE The prognostic value of myocardium deformation measurements in chronic heart failure (CHF) is still poorly addressed. The purpose of this study was to evaluate the correlation of left ventricular (LV) global longitudinal strain (GLS) with clinical and prognostic indicators in patients with CHF and systolic dysfunction. METHODS Ambulatory patients with CHF and LV eje...

OBJECTIVE To compare hemodynamic stress response (HDSR) to ET intubation using Glidescope (GLS) and Flexible fiberoptic laryngoscope (FFB). METHODS This prospective randomized comparative study was conducted at King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia from June 2011 - November 2013. Eighty ASA 1 & 2 patients with normal airway undergoing elective surgical pr...

In this paper, I consider generalized least squares (GLS) estimation in fixed effects panel and multilevel models with autocorrelation. A complication which arises in implementing GLS estimation in these settings is that standard estimators of the covariance parameters necessary for obtaining the feasible GLS estimates will typically be inconsistent due to the inclusion of individual specific f...

T experiment tested two behavioral properties of risky decision making—gain-loss separability (GLS) and coalescing. Cumulative prospect theory (CPT) implies both properties, but the transfer of attention exchange model (TAX) violates both. Original prospect theory satisfies GLS but may or may not satisfy coalescing, depending on whether editing rules are assumed. A configural form of CPT propos...

Recent work has highlighted glutaminase (GLS) as a key player in cancer cell metabolism, providing glutamine-derived carbon and nitrogen to pathways that support proliferation. There is significant interest in targeting GLS for cancer therapy, although the gene is not known to be mutated or amplified in tumors. As a result, identification of tractable markers that predict GLS dependence is need...

BACKGROUND Left ventricular global longitudinal systolic strain (GLS) has been shown to be superior to ejection fraction in detecting subclinical dysfunction in patients with cancer and predicting mortality in patients with cardiovascular disease. Cancer-related fatigue is common in the later stages of neoplastic malignancies and may be indicative of nonovert heart failure. The aim of this stud...

BACKGROUND Patients with type 2 diabetes mellitus (T2DM) are at high risk for cardiovascular events. The aim of the study was to assess whether global longitudinal strain (GLS) provides prognostic value in these patients. METHODS A total of 247 T2DM patients without history of cardiovascular complications and participated in the CDATS study were prospectively enrolled. Left ventricular (LV) s...

BACKGROUND Although global left ventricular systolic function is an important determinant of mortality, standard measures such as ejection fraction (EF) and wall motion score index (WMSI) have important technical limitations. The aim of this study was to compare global longitudinal speckle strain (GLS), an automated technique for measurement of long-axis function, with EF and WMSI for the predi...

BACKGROUND Global longitudinal strain (GLS) has emerged as a superior method for detecting left ventricular (LV) systolic dysfunction compared to ejection fraction (EF) on the basis that it is less operator dependent and more reproducible. The 2-dimensional strain (2DS) method is easily measured and integrated into a standard echocardiogram. This study aimed to determine the relationship betwee...