هدف : اول پژوهش حاضر شناسایی مقوله‌ها و مفاهیم تجاری‌سازی دانش جهت ارائه یک الگوی مفهومی است. دوم آن آزمون تجربی تجاری سازی می‌باشد.مواد روش‌ها: با راهبرد ترکیبی از نوع اکتشافی انجام شد. مشارکت‌کنندگان در رؤسا، مدیران گروه استادان دانشگاه، متخصصان مراکز رشد دانشگاهی پارک علم فناوری استان گیلان بودند. برای پژوهش، مرحله کیفی30 نفر استفاده نمونه‌گیری هدفمند کمی، 230 روش تصادفی طبقه‌ای به‌عنوان نمو...

هدف: هدف این پژوهش، تدوین استراتژی پاداش برای سازمان­‌های مشمول مدیریت خدمات کشوری است که بر اساس مدل هی­‌گروپ و شاخص‌­های کار شایسته انجام شده به عنوان مطالعه موردی، اداره کل تعاون، رفاه اجتماعی استان قم، در نظر گرفته است.طراحی/ روش‌شناسی/ رویکرد: با مراجعه مستندات منابع کتابخانه‌­ای اخذ خبرگان، مولفه­‌های موثر پرداخت پاداش‌­های اختیار سازمان سطح خرد (درون‌سازمانی)، شناسایی است. سپس مشارکت مصا...

To explain the pathophysiological significance of endogenous atrial natriuretic polypeptide (ANP) in the development of hypertension, we examined the effect of chronic, repetitive administrations of MAb raised against a-rat ANP in two rat models of hypertension, spontaneously hypertensive rats of the stroke prone substrain (SHR-SP), and deoxycorticosterone acetate (DOCA)-salt rats. Weekly intra...

To evaluate the role of extra-atrial atrial natriuretic peptide (ANP) in volume and blood pressure regulation, the plasma, atrial, ventricular, and hypothalamic levels of immunoreactive atrial natriuretic peptide (IR-ANP) were measured simultaneously in the spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) at the ages of 2, 6, and 12 months. Plasma IR-ANP in the 12-month-old, co...

Atrial secretion of atrial natriuretic peptide (ANP) has been shown to be regulated by atrial workload. Although modulating factors for the secretion of ANP have been reported, the role for intracellular Ca(2+) on the secretion of ANP has been controversial. The purpose of the present study was to define roles for L- and T-type Ca(2+) channels in the regulation of ANP secretion in perfused beat...

This study investigated the hypothesis that atrial natriuretic peptide (ANP) responses are mediated by particulate guanylate cyclase in the pulmonary vascular bed of the cat. When tone in the pulmonary vascular bed was raised to a high steady level with the thromboxane mimic U-46619, injections of ANP caused dose-related decreases in lobar arterial pressure. After administration of HS-142-1, an...

The main active form of atrial natriuretic peptide (ANP) in the circulation is alpha ANP(1-28) [gamma-ANP(99-126)], although some active and inactive metabolites are also though to be present. Some immunoassays for alpha ANP reportedly detect inactive metabolites, as determined by their comparison with results by receptor assay, which would lead to misleading results for alpha ANP(1-28) measure...

The atrial natriuretic peptide (ANP), a member of the natriuretic peptide family, is a cardiovascular hormone which possesses well defined natriuretic, diuretic, and vasodilating properties. Most of the biological effects of ANP aremediated through its guanylyl cyclase coupled A receptor. Because ANP and its receptors have been shown to be expressed and differentially regulated in the immune sy...

In vitro release of atrial natriuretic peptide (ANP) from atria was examined by ANP radioimmunoassay. Isolated right rat atria were incubated in Krebs-Ringer bicarbonate buffer, and test substances were added to the incubation medium. The fluid was assayed for rat ANP by a radioimmunoassay method recently developed in our laboratory. We produced an antiserum to human ANP(99-216) (alpha-hANP(1-2...