نتایج جستجو برای: متیلن تتراهیدروفولات ردوکتاز mthfr

تعداد نتایج: 4340  

Journal: :Genetic testing and molecular biomarkers 2012
Emel Ergul Ali Sazci Ihsan Kara

Attention-deficit/hyperactivity disorder (ADHD) is a common, multifactorial genetic disorder. The aim of the present study was to evaluate a possible association between 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and ADHD. There is evidence to suggest that MTHFR C677T and A1298C polymorphisms alter the function of the enzyme, causing reduced folate and increased homocys...

2015
Danielius Serapinas Klaudija DAUGĖLAITĖ Danielius SERAPINAS

Daugėlaitė K. and D. Serapinas (2015): The importance of mthfr gene mutation detection in patient with recurrent miscarriagesGenetika, Vol 47, No. 2, 609-616. Homocysteine is an enzyme encoded by MTHFR (methylenetetrahydrofolate reductase) gene located on chromosome 1. Mutations in MTHFR gene may result in the afflicted metabolism of homocysteine and thus might increase the risk of recurrent mi...

Journal: :Journal of the National Cancer Institute 2004
Kyoung-Jin Sohn Ruth Croxford Zoe Yates Mark Lucock Young-In Kim

BACKGROUND Although single nucleotide polymorphisms may be potentially important pharmacogenetic determinants of cancer therapy, functional evidence regarding their relevance is currently lacking. The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with changes in cellular composition of folates. We hypothesized that this polymorphism may modulate the cy...

Journal: :Neurology 2014
Gerarda Cappuccio Carla Cozzolino Giulia Frisso Roberta Romanelli Giancarlo Parenti Alessandra D'Amico Barbara Carotenuto Francesco Salvatore Ennio Del Giudice

Methylenetetrahydrofolate reductase (MTHFR) deficiency is a rare autosomal recessive disease included in the group of homocysteine remethylation disorders. The MTHFR catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. Besides the well-known association of thrombophilic defects with MTHFR variants and elevated homocysteine, few patients with MTHFR...

Journal: :Journal of the Korean neurological association 2022

Decrease in the activity of methylenetetrahydrofolate reductase (MTHFR) increases level homocysteine. MTHFR C677T gene polymorphism has been reported as a well-known cause elevated homocysteine associated with cerebral venous sinus thrombosis (CVST). A 34-year-old male was admitted severe headache after generalized seizure. Brain magnetic resonance venography showed thrombus superior sagittal s...

Afshin Abdirad, Akbar Oghalaie, Kazem Zendehdel, Mahmoud Eshagh Hossieni, Marjan Mohammadi, Maryam Bababeik, Maryam Esmaili, Mohammad Ali Mohagheghi, Najmeh Karami, Nazanin Mohajerani, Neda Amini, Parisa Hassanpour, Sahar Jahangiri, Samaneh Saberi, Yeganeh Talebkhan,

Background: Attempts for early detection of gastric cancer have recently focused on host's genetic susceptibility factors and gene-environment interactions. We have, herein, studied the association of MTHFR C677T single nucleotide polymorphism (SNP) and its interaction with Helicobacter pylori infection, smoking, age and gender on the risk of gastric cancer among an Iranian population. Methods:...

MH Sheikhha , N Ghasemi , S Soleimanian , SM Kalantar ,

Abstract Background Polymorphism A1298C of the methylenetetrahydrofolate-reductase (MTHFR) gene has been implicated in spontaneous abortion. In this study, we determined the allele and genotype frequencies of this polymorphism in recurrent spontaneous abortion (RSA) and implantation failure after in vitro fertilization (IVF). Materials and Methods We performed a case–control study on 60 wom...

Journal: :Anticancer research 2007
Doyeun Oh Nam Keun Kim Moon Ju Jang Hugh Chul Kim Jae Hoon Lee Jung Ae Lee Myung Ju Ahn Chul Soo Kim Heung Sik Kim Seonyang Park Hyun Sook Chio Yoo Hong Min

BACKGROUND Methylenetetrahydrofolate reductase (MTHFR) plays a central role in converting folate to methyl donor for DNA methylation. Because MTHFR is a key enzyme in folate metabolism, changes in its activity resulting from polymorphisms in the MTHFR gene could modify the susceptibility to cancer. Recently, the C677T and A1298C mutations of MTHFR were discovered to be associated with susceptib...

2018
Ya-Ling Yang Hsiao-Ling Yang S. Pamela K. Shiao

Hypertensive disorders in pregnancy (HDP) are devastating health hazards for both women and children. Both methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and air pollution can affect health status and result in increased risk of HDP for women. The major objective of this study was to investigate the effect of MTHFR polymorphisms, air pollution, and their interaction on the risk ...

Journal: :Allergologia et immunopathologia 2015
M Dogru H Aydin A Aktas A A Cırık

BACKGROUND Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms by impairing folate metabolism may influence the development of allergic diseases. The results of studies evaluating the relationship between MTHFR polymorphisms and atopic disease are controversial. The aim of this study was to investigate the association between the polymorphisms of C677T and A1298C for MTHFR gene and allerg...

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