Mongan, Paul D., John L. Fontana, Rouyan Chen, and Rolf Bünger. Intravenous pyruvate prolongs survival during hemorrhagic shock in swine. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H2253–H2263, 1999.—Pyruvate improves cellular and organ function during hypoxia and ischemia and stabilizes the NADH redox state and cytosolic ATP phosphorylation potential. In this in vivo study, we evaluated th...

Carbajal, José M., and Richard C. Schaeffer, Jr. RhoA inactivation enhances endothelial barrier function. Am. J. Physiol. 277 (Cell Physiol. 46): C955–C964, 1999.—The modulation of endothelial barrier function is thought to be a function of contractile tension mediated by the cell cytoskeleton, which consists of actomyosin stress fibers (SF) linked to focal adhesions (FA). We tested this hypoth...

HIROYASU TSUKAGUCHI,1 STANISLAWA WEREMOWICZ,2 CYNTHIA C. MORTON,2 AND MATTHIAS A. HEDIGER2,3 1Membrane Biology Program and Renal Division, Department of Medicine, and 2Departments of Pathology and Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital and Harvard Medical School, and 3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Bo...

Ning, Xue-Han, Cheng-Su Xu, and Michael A. Portman. Mitochondrial protein and HSP70 signaling after ischemia in hypothermic-adapted hearts augmented with glucose. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R11–R17, 1999.—Hypothermia improves resistance to subsequent ischemia in the cardioplegic-arrested heart (CAH). This adaptive process produces mRNA elevation for heat sho...

Champion, Hunter C., Trinity J. Bivalacqua, David G. Lambert, Rasheed A. Abassi, and Philip J. Kadowitz. Analysis of vasoconstrictor responses to histamine in the hindlimb vascular bed of the rabbit. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1179–R1187, 1999.—Hemodynamic responses to histamine were investigated in the anesthetized rabbit. Intravenous injections of histami...

Hughes, Jeremy, and Richard J. Johnson. Role of Fas (CD95) in tubulointerstitial disease induced by unilateral ureteric obstruction. Am. J. Physiol. 277 (Renal Physiol. 46): F26–F32, 1999.—Murine renal tubular epithelial cells and interstitial fibroblasts may express both Fas (CD95) death receptor and Fas ligand and are vulnerable to Fas-mediated death in vitro. We therefore hypothesized that a...

Shirasaka, Tetsuro, Masamitsu Nakazato, Shigeru Matsukura, Mayumi Takasaki, and Hiroshi Kannan. Sympathetic and cardiovascular actions of orexins in conscious rats. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1780–R1785, 1999.—The novel hypothalamic peptides orexin-A and orexin-B are known to induce feeding behavior when administered intracerebroventricularly, but little is...

Butler, Karyn L., Alice H. Huang, and Judith K. Gwathmey. AT1-receptor blockade enhances ischemic preconditioning in hypertrophied rat myocardium. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H2482–H2487, 1999.—The purpose of this study was to determine whether ischemic preconditioning protects contractile function in hypertrophied rat myocardium from ischemia-reperfusion (I/R) injury. Male s...

Arai, Andrew E., Claudia E. Kasserra, Paul R. Territo, Amir H. Gandjbakhche, and Robert S. Balaban. Myocardial oxygenation in vivo: optical spectroscopy of cytoplasmic myoglobin and mitochondrial cytochromes. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H683–H697, 1999.— The oxygenation state of myoglobin and the redox state of cytochrome c provide information on the PO2 in the cytosol and mi...