The SNAP receptor (SNARE) complex, consisting of synaptosome-associated protein of 25 kDa (SNAP-25), synaptobrevin-2, and syntaxin-1, is involved in synaptic vesicles exocytosis. In addition, SNAP-25 has been implicated in constitutive exocytosis processes required for neurite outgrowth. However, at least three isoforms of SNAP-25 have been reported from neurons: SNAP-23, which is also present ...

background: accurate impression making is an essential prerequisite for achieving a passive fi t between the implant and the superstructure. the aim of this in vitro study was to compare the three-dimensional accuracy of open-tray and three closed-tray impression techniques. materials and methods: three acrylic resin mandibular master models with four parallel implants were used: biohorizons (b...

Introduction Vesico-ureteric reflux (VUR) is a congenital disorder of the paediatric renal tract, which allows the retrograde passage of urine up to the renal pelvis, predisposing to renal infection and consequential scarring, hypertension and renal failure. The current gold standard for diagnosis is the Micturating Cystourethrogram (MCUG), allowing snap-shot imaging of the urethra, bladder and...

Neuronal dense-core vesicles (DCVs) transport and secrete neuropeptides necessary for development, plasticity and survival, but little is known about their fusion mechanism. We show that Snap-25-null mutant (SNAP-25 KO) neurons, previously shown to degenerate after 4 days in vitro (DIV), contain fewer DCVs and have reduced DCV fusion probability in surviving neurons at DIV14. At DIV3, before de...

objective: evaluation and diagnosis are determinants of treatment outcome; therefore, diagnostic tools should be accurate. the purpose of the present research is construction and norm-finding of a rating scale for the diagnosis of attention deficit hyperactivity disorder (adhd). method: a checklist based on behavioral symptoms of adhd from clinical sources was constructed, based on interview wi...

AIM To evaluate collaborative problem solving (CPS) in Swedish 6-13-year-old children with attention-deficit/hyperactivity disorder and oppositional defiant disorder (ODD). METHODS Seventeen families completed 6-10 sessions of CPS training. Primary outcome measures were SNAP-IV [attention-deficit/hyperactivity disorder (ADHD) and ODD scores] and Clinical Global Impression-Improvement (CGI-I) ...

The cardiovascular manifestations of the mucopolysaccharidoses (MPS) have not been well characterized. We studied nine children with various forms of MPS, using noninvasive cardiac diagnostic techniques. The echocardiograms of two brothers with Type I H/S MPS showed slow mitral valve early diastolic closure velocities (MVEDC) (18, 29 mm/sec) consistent with mitral stenosis. Each had a soft open...