Higgs, Penelope Coordination of cell fates is mediated by negative regulatory signaling systems in the Myxococcus xanthus multicellular developmental program 4 BREAK Boll, Joseph Michael A specificity determinant in a response regulator prevents in vivo crosstalk and phosphorylation by non-cognate phosphodonors 5 Pawelczyk, Sonja Prediction of interspecies cross-talk in two-component systems 6 ...

The transistor circuit research is aimed at problems of general interest in communication engineering. Fundamental principles of transistor circuit design and practical limitations imposed by available devices are being investigated for circuits useful in a wide variety of applications. Present studies include work on sweep generators, temperature effects in dc amplifiers, and methods of stabil...

[Cp(*)RhCl(PTA)(2)]X (PTA = 7-phospha-1,3,5-triazaadamantane) undergoes an H/D exchange process between the methyl groups of Cp(*) and D(2)O whose rate depends on the coordinating ability of the counterion X(-). Kinetic studies and DFT calculations indicate that deuteration involves the abstraction of a Me-Cp(*) proton by a coordinated OH(-); the formation of the latter seems to be facilitated ...

We study the nonequilibrium statistical mechanics of a finite classical system subjected to nongradient forces xi and maintained at fixed kinetic energy (Hoover-Evans isokinetic thermostat). We assume that the microscopic dynamics is sufficiently chaotic (Gallavotti-Cohen chaotic hypothesis) and that there is a natural nonequilibrium steady-state rho(xi). When xi is replaced by xi + deltaxi, on...

Using competitive binding experiments, it was found that native type XI collagen binds heparin, heparan sulfate, and dermatan sulfate. However, interactions were not evident with hyaluronic acid, keratan sulfate, or chondroitin sulfate chains over the concentration range studied. Chondrocyte-matrix interactions were investigated using cell attachment to solid phase type XI collagen. Pretreatmen...

X chromosome inactivation (XCI) is the most dramatic example of epigenetic silencing in eukaryotes. Once established, the inactivated X chromosome (Xi) remains silenced throughout subsequent cell divisions. Though the initiation of XCI has been studied extensively, the protein factors involved in Xi silencing and maintenance are largely unknown. Here we report the discovery of a diverse set of ...

Binding sites for high molecular weight kininogen (HK) and for factor XIIa are present in the Apple 1 (A1) and the A4 domains of factor XI, respectively. To define the roles of these two sites in surface-mediated factor-XI activation we prepared conformationally constrained synthetic peptides and recombinant A1 domain (rA1) and determined their effects on the activation of factor XI by factor X...

A fine-grained dual-process approach to conditional reasoning is advocated: Responses to conditional syllogisms are reached through the operation of either one of two systems, each of which can rely on two different mechanisms. System1 relies either on pragmatic implicatures or on the retrieval of information from semantic memory; System2 operates first through inhibition of System1, then (but ...

1. Kali: This "Devourer of Time" is worshipped as the very essence of the Brahman or the Supreme Self. Kali is regarded as the Supreme Deity of Kalikula systems 2. Tara: The Goddess who Saves, Guides and Protects. She offers the ultimate knowledge necessary for salvation. This Mahavidya is also known as Neel Saraswati 3. Lalita Tripura-Sundari: The Goddess, also known as Shodashi, is the One Wh...