The c-myb proto-oncogene product (c-Myb) can transactivate the human hsp70 promoter in a transient cotransfection assay. The present studies have demonstrated that the heat shock element (HSE) in the hsp70 promoter mediates trans-activation by c-Myb. Mutagenesis of the DNA sequence in HSE indicated that the NGAAN motif is necessary for not only the heat shock response but also the c-Myb-induced...

The factors which cause herpes simplex encephalitis (HSE) to occur among herpes simplex virus type 1 (HSV-1) infected humans are not understood. In experimental models, HSV-1 neuroinvasiveness is influenced by amino acid changes in HSV glycoproteins D (gD) or B (gB), which are essential to the virus infectivity and to the induction of host immune responses. To test the possible involvement of t...

L O’Connor ([email protected])1, M Ward1, D Bennett2, R Mulhall2, P O’Lorcain3, R Cunney2,3, R McDermott1, E Neville4, J Heslin4, R FitzGerald5, K Meyler2, M Conlon1, A Clarke1, B Corcoran6, G Fitzpatrick1, B O’Connor4, P Flanagan3, D O’Flanagan3, S Cotter3 1. Department of Public Health, HSE East, Dr Steevens’ Hospital, Dublin, Ireland 2. Epidemiology and Molecular Biology Unit, Temple ...