This study was undertaken to examine the effect and mechanism of Bofu-tsusho-san formula (BO) on hyperglycemia and hyperlipidemia and in mice fed with a high-fat (HF) diet. The C57BL/6J mice were received control/HF diet for 12 weeks, and oral administration of BO (at three doses) or rosiglitazone (Rosi) or vehicle for the last 4 weeks. Blood, skeletal muscle and tissues were examined by means ...

Information permeates our world, and in many forms: data on disk, knowledge in an expert’s mind, statistical observations of the natural world. To make decisions or predictions – treatments in health care, climate and public policy, user behavior and suggestions in e-commerce – we seek to understand and design systems for acquiring, aggregating, and acting on that information. Such systems can ...

Every individual has a unique body odor (BO), similar to a fingerprint. In forensic research, identification of culprit BOs has been performed by trained dogs, but not by humans. We introduce the concept of nosewitness identification and present the first experimental results on BO memory in witness situations involving violent crimes. Two experiments indicated that BO associated with male char...

Barrett’s oesophagus (BO) is an acquired pre-malignant condition in which metaplastic columnar epithelium replaces the normal squamous mucosa as a consequence of chronic gastro-oesophageal reflux. The pre-malignant quality of BO is demonstrated in untreated adults with BO which are at risk of Barrett-associated adenoacarcinoma (BAA). This review addresses the epidemiological, clinical, endoscop...

The therapeutic effect in non-small cell lung cancer (NSCLC) patients is limited because of intrinsic and acquired resistance. Thus, an unmet need exists for the development of new drugs to improve the therapeutic efficacy in NSCLC patients. In this study, the novel small molecule indolizino[6,7-b]indole derivative BO-1978 was selected to evaluate its therapeutic effects on NSCLC and its precli...

BACKGROUND Noncompressible torso hemorrhage is the leading cause of potentially preventable death on the modern battlefield. The objective of this study is to characterize resuscitative aortic balloon occlusion (BO) compared to thoracotomy with aortic clamping in a model of hemorrhagic shock. METHODS A total of 18 swine (3 groups; 6 animals/group) were used in this study. Swine in class IV sh...