It was recently shown that capture of HIV-1 by DC-SIGN-expressing cells and the subsequent transmission of HIV to CD4+ T-lymphocytes can be prevented by carbohydrate-binding agents (CBAs), whereas polyanions were unable to block virus capture by DC-SIGN. In this study, we could show that a short pre-exposure of HIV-1 to both mannose- and N-acetylglucosamine (GlcNAc)-specific CBAs or polyanions ...

Dendritic cells (DC) are antigen-presenting cells uniquely capable of priming naïve T cells and cross-presenting antigens, and they determine the type of immune response elicited against an antigen. TAT peptide (TATp), is an amphipathic, arginine-rich, cationic peptide that promotes penetration and translocation of various molecules and nanoparticles into cells. TATp-liposomes (TATp-L) used for...

Given a right coprime MFD of a strictly proper plant P(s) = NR(s)DR(s)−1 with DR(s) column proper a simple numerical algorithm is derived for the computation of all polynomial solutions [X L (s), YL (s)] of the polynomial matrix Diophantine equation X L (s)DR(s)+YL (s)NR(s) = DC (s) which give rise to the class Φ(P, DC ) of proper compensators C(s) := X L (s)−1YL (s) that when employed in a uni...

The hypercube Qn is one of the most well-known and popular interconnection networks and the k-ary n-cubeQn is an enlarged family from Qn that keeps many pleasing properties from hypercubes. In this article, we study the panpositionable hamiltonicity of Qn for k ≥ 3 and n ≥ 2. Let x, y of V (Qn) be two arbitrary vertices and C be a hamiltonian cycle of Qn. We use dC(x, y) to denote the distance ...

We observe a correspondence between the zero modes of superconformal algebras S(2, 1) and W (4) ([8]) and the Lie superalgebras formed by classical operators appearing in the Kähler and hyper-Kähler geometry. 1 Lie superalgebras of the Hodge theory 1.1 Kähler manifolds Let M = (M2n, g, I, ω) be a compact Kähler manifold of real dimension 2n, where g is a Riemannian (Kähler) metric, I is a compl...

This paper explores a configuration for boost half bridge DC-DC converters, connected in parallel at the input and series at the output, such that the converters share the input current and load voltage equally. A stable control scheme has been developed to achieve this objective. In order to verify the effectiveness and stability of control scheme, input-parallel output-series (IPOS) connected...

the aim of this paper is to design a fractional order sliding mode controllers (fosmc)for a class of dc-dc converters such as boost and buck converters. firstly, the control lawis designed with respect to the properties of fractional calculus, the design yields an equiv-alent control term with an addition of discontinuous (attractive) control law. secondly, themathematical proof of the stabilit...

The molecular mechanisms involved in the hepatic tropism of hepatitis C virus (HCV) have not been identified. We have shown previously that liver-expressed C-type lectins L-SIGN and DC-SIGN bind the HCV E2 glycoprotein with high affinity (Lozach, P. Y., Lortat-Jacob, H., de Lacroix de Lavalette, A., Staropoli, I., Foung, S., Amara, A., Houles, C., Fieschi, F., Schwartz, O., Virelizier, J. L., A...

Toll-like receptor ligands (TLR-L) represent novel vaccine adjuvants, but their immunological effects in humans in-vivo remain poorly defined. Here we analyzed the innate responses stimulated by different TLR-L in rhesus macaques, a relevant preclinical model for vaccine testing. MPL (TLR4-L), R-848 (TLR7/8-L) or CpG-ODN (TLR9-L) induced rapid (3hr) and robust (>92% of WBC) expansion of blood n...