BACKGROUND Cystatin C is a promising new biomarker to determine the estimated glomerular filtration. However, the Siemens' cystatin C assay (Siemens), used in many longitudinal studies, has had limited clinical applicability because it requires a specific, dedicated instrument. Other companies, including Gentian and Roche, have developed cystatin C assays that can be used with most routine clin...

3. Katsoulidou A, Petrodaskalaki M, Sypsa V, et al. Evaluation of the clinical sensitivity for the quantitation of human immunodeficiency virus type 1 RNA in plasma: comparison of the new Cobas TaqMan HIV-1 with three current HIV-RNA assays–LCx HIV RNA quantitative, Versant HIV-1 RNA 3.0 (bDNA) and Cobas Amplicor HIV-1 Monitor v1.5. J Virol Methods 2006; 131:168–74. 4. Damond F, Roquebert B, Be...

The purpose of this experiment was to determine if tolerance toexercise in the heat is related to maximal oxygen uptake (max _'02) and sweating.Seven men with max _'02 between 42 and 66 ml/(min-kg) underwent one 2-hr e.xpo-sure at 24°C T_ while working on a bicycle ergometer at _ tel V02 of 28%(5 V'02 = 1.23 lJ'min). In the hot exposures the high capacity subjects had maximal<lb...

Two unrelated patients underwent coronary angiography and a percutaneous intervention. At the end of the procedures, blood was collected (Vacutainer® SSTTM; BD) for troponin, creatine kinase (CK), and CK-MB isoenzyme analysis. After centrifugation with the Roche Modular Pre-Analytics system (Roche Diagnostics), pipetting error alerts were triggered on the aliquoting module of the Pre-Analytics ...

The rapid and reliable diagnosis of acute myocardial infarction is a major unmet clinical need. We conducted a multicenter study to examine the diagnostic accuracy of new, sensitive cardiac troponin assays performed on blood samples obtained in the emergency department from 718 consecutive patients who presented with symptoms suggestive of acute myocardial infarction. Cardiac troponin concentra...