This paper presents a method for making nonaudible murmur (NAM) enhancement based on statistical voice conversion (VC) robust against external noise. NAM, which is an extremely soft whispered voice, is a promising medium for silent speech communication thanks to its faint volume. Although such a soft voice can still be detected with a special body-conductive microphone, its quality significantl...

The purpose of this study is to investigate whether nicotinic acid (NA) and nicotinamide (NAM) reduce the Alzheimer disease (AD)-related gene expression in brain tissues of amyloid beta (Aβ)-injected mice. Male Crj:CD1 (ICR) mice were divided into 6 treatment groups; 1) control, 2) Aβ control, 3) Aβ + NA 20 mg/kg/day (NA20), 4) Aβ + NA40, 5) Aβ + NAM 200 mg/kg/day (NAM200), and 6) Aβ + NAM400. ...

We test the ability of the numerical action method (NAM) to recover the individual orbit histories of mass tracers in an expanding universe in a region of radius 26 hMpc, given the masses and redshift-space coordinates at the present epoch. The mass tracers are represented by dark matter haloes identified in a high resolution N -body simulation of the standard ΛCDM cosmology. Since previous tes...

[1] We show that the reconstructed sensitivity of the sea level temperature to long term solar forcing in the Northern Hemisphere is in very good agreement with the empirical temperature pattern corresponding to changes of the North Annular Mode (NAM). This implies that long-term variations of solar output affect climate predominantly through the NAM that extends throughout the stratosphere and...

Poly(ADP-ribose) polymerase (PARP) inhibitors enhance the effect of DNA alkylating agents on BRCA1‑ and BRCA2-deficient cell lines. The aim of this study was to analyze the effect of the PARP inhibitor nicotinamide (NAM) on breast cancer cells with different BRCA1 expression or function, such as BRCA1‑deficient MDA-MB-436 cells, low expression BRCA1 MCF-7 cells, and the BRCA1 wild‑type MDA-MB-2...

Under various appropriate hypotheses it is shown that there is only one determinacy model of the form L(R, μ) in which μ is a supercompact measure on Pω1(R). This gives a positive answer to a question asked by W.H. Woodin in 1983.

Recent research has shown that the subskills and text types affect reader performance considerably (Lumley, 1993, Dennis, 1982). Despite the fact that most reading tests consist of a variety of subskills and text types at the same time, the studies about the relative effects of both subskills and text types on readers’ performance are rare. In that vein, this article reports the relative effect...

Being composed of several whorls of distinct floral organs, the flower is one of the most complex organs in the plant. As such, the formation and maintenance of boundaries that separate the meristem from the floral organ primordium and adjacent organs are critical for its normal development. In Arabidopsis, the miR164-regulated NAM genes play key roles in floral-boundary specification. By contr...

Nicotinamide (NAM) plays essential roles in physiology through facilitating NAD+ redox homeostasis. Importantly, at high doses, it protects cells under oxidative stresses, and has shown therapeutic effectiveness in a variety of disease conditions. In our previous studies, NAM lowered reactive oxygen species (ROS) levels and extended cellular life span in primary human cells. In the treated cell...