New management practices must be developed to improve yam productivity. By allowing non-destructive analyses of important plant traits, image-based phenotyping techniques could help developing such practices. Our objective was determine the potential methods assess traits relevant for tuber yield formation in grown glasshouse and field. We took leaf pictures with consumer cameras. used numbers ...

Nanocarrier-based delivery systems are promising strategies for enhanced therapeutic efficacy and safety of toxic drugs. Photodynamic therapy (PDT)-a light-triggered chemical reaction that generates localized tissue damage for disease treatments-usually has side effects, and thus patients receiving photosensitizers should be kept away from direct light to avoid skin phototoxicity. In this study...

It has been reported that X-ray induced HPRT- mutation in cultured human cells is prevented by ascorbate added after irradiation. Mutation extinction is attributed to neutralization by ascorbate, of radiation-induced long-lived radicals (LLR) with half-lives of several hours. We here show that post-irradiation treatment with ascorbate (5 mM added 30 min after radiation) reduces, but does not el...

Background: In vitro studies have shown that CDK12 inhibition (CDK12i) leads to DNA damage accumulation, cell cycle arrest, and mitotic defects which result in antiproliferation. modeling translation vivo can elucidate the PK-PD-efficacy relationship of CDK12i subsequently simulate efficacy new dosing regimens. The goal this work was develop a mechanistic model describe effect on proliferation ...

Recently, we have proposed a new framework for early stages solidification, in which heterogeneous nucleation and grain initiation been treated as separate processes. In this paper, extend our atomic-level understanding of to spherical cap formation on single substrate using molecular dynamics calculations. We first show that can be generally described three-layer mechanism generate two-dimensi...

Introdução: A doença de Crohn (DC) caracteriza-se pela inflamação crônica do trato gastrointestinal (TGI), com padrão acometimento segmentar e transmural. Pode afetar qualquer parte TGI, sendo mais comum no íleo terminal cólon proximal. etiologia depende da interação entre microbiota intestinal, solução continuidade mucosa fatores genéticos. Sua incidência tem aumentado em países recentemente i...

Purpose: Selective inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) represents a promising therapeutic strategy. However, despite documented evidence of clinical activity, limited information is available on the optimal dosing strategy of CDK4/6 inhibitors. Here, we present an integrated semimechanistic pharmacokinetic/pharmacodynamic model to characterize the quantitative pharmacology o...

BACKGROUND AND PURPOSE Neurogenesis has been observed in the dentate gyrus of the adult hippocampus; however, the mechanisms involved in this process are still only partly understood. In this study, we visualized the proliferation, migration, and differentiation of neuronal progenitor cells in the dentate gyrus induced by ischemic stress using improved retroviral vector. METHODS Improved retr...

Peloruside A is a microtubule-stabilizing agent isolated from a New Zealand marine sponge. Peloruside prevents growth of a panel of cancer cell lines at low nanomolar concentrations, including cell lines that are resistant to paclitaxel. Three xenograft studies in athymic nu/nu mice were performed to assess the efficacy of peloruside compared with standard anticancer agents such as paclitaxel, ...