IMPORTANT FOR THE INTERPRETATION OF BOLD FMRI DATA IS A LINEAR RELATIONSHIP BETWEEN THE BOLD RESPONSE AND THE UNDERLYING NEURAL ACTIVITY: increased BOLD responses should reflect proportionate increases in the underlying neural activity. While previous studies have demonstrated a linear relationship between the peak amplitude of the BOLD response and neural activity in primary visual cortex (V1)...

The mechanisms underlying the transition from interictal to ictal states are poorly understood. Non-linear mathematical analysis of EEG frequency components has confirmed the presence of a pre-ictal state in focal epilepsy. We report on functional MRI (fMRI) analysis of the pre-ictal state in three patients with intractable focal epilepsy. Each subject had a typical partial seizure in the scann...

Arterial spin labeling-based cerebral blood flow imaging complements blood oxygenation level dependent (BOLD) imaging with a measure that is more quantitative and has better specificity to neuronal activation. Relative to gradient echo BOLD, spin echo BOLD has better spatial specificity because it is less biased to large draining veins. Although there have been many studies comparing simultaneo...