Bortezomib (BTZ) is a proteasome inhibitor approved in the treatment of multiple myeloma (MM). Bortezomib-induced peripheral neuropathy (BIPN) is an unpredictable dose-limiting adverse event in one-third of patients. In the present study, 58 relapsed/refractory MM patients treated with BTZ were analyzed. The study's aim was to compare BIPN incidence and severity between both groups and to ident...

New therapies for glioblastoma (GBM) are needed, as five-year survival is <10%. The proteasome inhibitor marizomib (MRZ) has inhibitory and death-inducing properties unique from previous inhibitors such as bortezomib (BTZ), and has not been well examined in GBM. We evaluated the mechanism of death and in vivo properties of MRZ in GBM. The activation kinetics of initiator caspases 2, 8, and 9 we...

Bortezomib (BTZ), a proteasome inhibitor, is the first proteasome inhibitor to be used in clinical practice. Here we investigated the mechanisms underlying acquired bortezomib resistance in hepatocellular carcinoma (HCC) cells. Using stepwise selection, we established two acquired bortezomib-resistant HCC cell lines, a bortezomib-resistant HepG2 cell line (HepG2/BTZ) and bortezomib-resistant Hu...

We investigate solutions of new massive gravity with two commuting Killing vectors, one of which is null, with a special emphasis on black hole solutions. Besides extreme BTZ black holes and, for a special value of the coupling constant, massless null warped black holes, we also obtain for a critical coupling a family of massive “log” black holes. These are asymptotic to the extreme BTZ black h...

The emission rate of fermions from 2+1 dimensional BTZ black holes is shown to have a form which can be reproduced from a conformal field theory at finite temperature. The rate obtained for fermions is identical to the rate of non-minimally coupled fermions emitted from a five dimensional black hole, whose near horizon geometry is BTZ × M , where M is a compact manifold. 04.60.-m,04.62.+v,04.70...

We extend our recent discussion of four-dimensional black holes bound to a two-brane to include a negative cosmological constant on the brane. We find that for large masses, the solutions are precisely BTZ black holes on the brane, and BTZ ‘black strings’ in the bulk. For smaller masses, there are localized black holes which look like BTZ with corrections that fall off exponentially. We compute...

In order to enhance the charge balance of organic near infrared (NIR) electroluminescent devices, an ancillary ligand pic-SCz which was covalently linking bipolar group SCz (composed PS (S) and tBuCz (Cz)) pic (SCz=3,6-di-tert-butyl-9-(4-(phenylsulfonyl)phenyl)-9H-carbazole; = phenyl sulfone; 3,6-di-tert-butylcarbazole; pic= 2-picolinic acid) developed for iridium (III) complex (TPA-BTz-Iq)2Ir(...

We study aspects of the propagation of strings on BTZ black holes. After performing a careful analysis of the global spacetime structure of generic BTZ black holes, and its relation to the geometry of the SL(2, R) group manifold, we focus on the simplest case of the massless BTZ black hole. We study the SL(2, R) Wess-Zumino-Witten model in the worldsheet minisuperspace limit, taking into accoun...

We study the wave equation for a massive scalar in three-dimensional AdS-black hole spacetimes to understand the unitarity issues in a semiclassical way. Here we introduce four interesting spacetimes: the non-rotating BTZ black hole (NBTZ), pure AdS spacetime (PADS), massless BTZ black hole (MBTZ), and extremal BTZ black hole (EBTZ). Our method is based on the potential analysis and solving the...