Oncolytic viruses (OVs) comprise an emerging cancer therapeutic modality whose activity involves both direct tumor cell lysis and the induction of immunogenic cell death (ICD). Cellular proteins released from the OV-lysed tumor cells, known as damage-associated molecular patterns and tumor-associated antigens, activate dendritic cells and elicit adaptive antitumor immunity. Interaction with the...

Oncolytic viruses (OVs) are emerging as promising and potential anti-cancer therapeutic agents, not only able to kill cancer cells directly by selective intracellular viral replication, but also promote an immune response against tumor. Unfortunately, the bioavailability under systemic administration of OVs is limited because undesired inactivation caused host system neutralizing antibodies in ...

This article aims to explore the characteristics of computed tomography (CT) images of ovarian vein syndrome (OVS). The approval of the research ethics committee and the written informed consent of the patients were obtained. The CT images of 11 patients who had been diagnosed with OVS were retrospectively analyzed. All patients were examined with CT urogram, both plain CT scans and enhanced CT...

INTRODUCTION Brachytherapy may be complicated by serious obstructive voiding symptoms (OVS). Only conservative treatment options are available in the first 6 months after brachytherapy. We evaluated safety, efficacy and patient tolerance of the Memokath prostatic stent (MPS). MATERIAL AND METHODS A MPS was placed in 10 patients with OVS after brachytherapy. Evaluation included uroflowmetry, i...

The oncolytic virotherapy field has made significant advances in the last decade, with a rapidly increasing number of early- and late-stage clinical trials, some of them showing safety and promising therapeutic efficacy. Targeting tumor vasculature by oncolytic viruses (OVs) is an attractive strategy that offers several advantages over nontargeted viruses, including improved tumor viral entry, ...

Oncolytic viruses (OV) are replicating viral therapeutics for the treatment of cancer and have been in laboratory development for about twenty years. Recently, the FDA approved Imlygic, a herpes virus based therapeutic for the treatment of melanoma and thus OVs have entered a new era where they are a weapon in the armament of the oncologist. OVs are unique therapeutics with multiple mechanisms ...

The compact polarimetric (CP) synthetic aperture radar (SAR) can alleviate the drawbacks of fully (FP) SAR and provide more target information as compared to conventional single dual mode. However, present decomposition methods for CP have problem overestimation volume scattering (OVS) among urban areas, especially obliquely oriented buildings (OOBs). OVS cause considerable which leads misinter...

Introduction: Outer volume suppression (OVS) pulses have long been used to improve localization properties of MRS acquisition sequences. For saturation pulses, there is no need to reach 180° and there is no phase requirement for the crushed signal. Therefore, they can be constructed to feature steep profiles and high bandwidth providing reduced chemical shift artifacts (CSA) [1]. These properti...

High Mobility Group Box 1 (HMGB1) is a multifunctional protein that plays various roles in the processes of inflammation, cancer, and other diseases. Many reports document abundant HMGB1 release following infection with oncolytic viruses (OVs). Further, other groups including previous reports from our laboratory highlight the synergistic effects of OVs with chemotherapy drugs. Here, we show tha...

We examined the role of spatial representations and word order on thematic role assignment in Greek. Previous studies suggest that spatial representations influence thematic role assignment; agent is typically depicted on the left, and patient on the right. Here, we address this issue using a language with flexible word order which allows us to manipulate sentence structure (SVO–OVS) orthogonal...