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تناوبهایِ کوتاهِ پالیندرومِ فاصلهدارِ منظمِ خوشهای (clustered regularly interspaced short palindromic repeats) ، سیستم های CRISPR- Cas ، سیستم های ایمنی به دست آمده شناخته شده است که در آرکیا و باکتری ها گسترده است. نوکلئاز های RNA راهنما از سیستم های CRISPR- Cas در حال حاضر به عنوان ابزار قابل اعتماد برای ویرایش و مهندسی ژنوم در نظر گرفته شده است. نخستین اشاره به آنها در سال 1987 بود، زمانی که د...
background : ruptured cerebral aneurysms (icas) are the most common non-traumatic cause of subarachnoid hemorrhage (sah) that is associated with life threatening complications such as vasospasm, infarction, and hydrocephalus (hcp). the active participation of macrophage/monocyte-mediated inflammatory response in the pathogenesis of cerebral aneurysm as labeled with monocyte chemoattractantprote...
le mouvement transversal de la locomotive ou des wagons , appele ie lacet, provient de deux causes principales: -la conicite des bandages -les irregularites de la voie dans ie plan horizontal. on se propose ici d'etudier la premiere cause , ce qui nous conduit a une equation differentielle non lineaire du deuxieme ordre. • l'equation en question est etudiee dans plusieurs cas difftten...
approximately all sequenced archaeal and half of eubacterial genomes have some sort of adaptive immune system, which enables them to target and cleave invading foreign genetic elements by an rnai-like pathway. crispr–cas (clustered regularly interspaced short palindromic repeats–crispr-associated proteins) systems consist of the crispr loci with multiple copies of a short repeat sequence separa...
مقدمه: ریزوبیومها باکتریهایی هستند که با گیاهان زراعی خانوادۀ لگوم همزیستی دارند. باکتریهای ریزوبیومی علاوه بر تثبیت نیتروژن، قابلیتهای دیگری از جمله توانایی تولید آمینو سیکلوپروپان کربوکسیلات دآمیناز (ACC دآمیناز[i]) و سیدروفور را دارند، در ایجاد گرهکهای بیشتر در شرایط مختلف محیطی موفقتر خواهند بود. هدف از این مطالعه، غربال سویههای رایزوبیومی بومی تولیدکنندۀ آنزیم ACC دآمیناز و سیدروفور...
Sialic acids, terminal sugars of glycoproteins and glycolipids, play important roles in development, cellular recognition processes and host-pathogen interactions. A common modification of sialic acids is 9-O-acetylation, which has been implicated in sialoglycan recognition, ganglioside biology, and the survival and drug resistance of acute lymphoblastic leukaemia cells. Despite many functional...
abstract cyanide is a colorless, harmful, and dangerous substance with a smell similar to bitter almond. cyanide forms a stable compound with iron and magnesium and interferes with cell activity by interfering with respiration, carbon stabilization and nitrate revival. in order to evaluate cyanide metabolism in fuji and abassi mashhad apples, a factorial experiment was conducted as split plot b...
In this paper, based on CAS wavelets we present quadrature rules for numerical solution of double and triple integrals with variable limits of integration. To construct new method, first, we approximate the unknown function by CAS wavelets. Then by using suitable collocation points, we obtain the CAS wavelet coefficients that these coefficients are applied in approximating the unk...
The title compound, C(20)H(30)O(2), {systematic name: (4aR,6aS,7R,11aS,11bR)-4,4,7,11b-tetra-methyl-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodeca-hydro-phenanthro[3,2-b]furan-4a-ol}, is a cas-sane furan-oditerpene which was isolated from the roots of Caesalpinia pulcherrima. The absolute configurations at positions 4a, 6a, 7, 11a and 11b are R, S, R, S and R, respectively. The mol-ecule has four-fused ...
TIROS I observed :tn extratropical cyclone near Hcxrrnuda on t,hree occasions in early hIay 1960 during the last 86 hours of the life cycle of the storm. A study of this cas^ was undertaken with three objectives in mind: (a) t o describe interesting features of the organizat,ion manifested in the cloud patterns and compare these with conventional analyses; (b) to present a subjective interpreta...
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