نتایج جستجو برای: سلول huh7

تعداد نتایج: 15913  

Objective(s): Hepatocellular carcinoma (HCC) is one of the most significant health condition around the world. As the only curative therapies, liver transplantation and surgical resection are the clinical treatments of HCC. Due to the systemic toxicity and severe side effects of these treatments, it is vital to establish new therapeutic approaches. The present study ai...

Cell-based biosensors (CBBs) are becoming important tools for biosecurity applications and rapid diagnostics in food microbiology for their unique capability of detecting hazardous materials. Pollutants, such as heavy metals and chemicals, are now considered as a global threat and are associated with detrimental health outcomes. Fast and accurate detection of pollutants is essential to reduce t...

Journal: :Annals of Oncology 2022

The study of the role oncosuppressors in tumor transformations and death cells is an important aspect many areas biochemistry. One most well-known suppressors p53 protein. function protein to regulate expression genes whose products lead cell cycle arrest apoptosis. Many types cancer are associated with inactivation suppressor as a result mutation. p53Y220C oncogenic mutation it creates extende...

Journal: : 2023

انتقال ویروس کرونا به داخل سلول از طریق اسپایک‌های انجام می‌شود پس یکی بهترین راه‌های مقابله با سلول‌های بدن، ایجاد اختلال در روند عملکرد است. بنابراین این تحقیق، چگونگی جذب و انرژی پرتوهای رادیواکتیو سارس کووید2، مرس کووید، یوکی کووید توسط ابزار جینت4- دی اِن اِی شبیه‌سازی شده نتایج حاصل پرتودهی اسپایک‌ها یکدیگر مقایسه آن‌جایی که عوامل کاهش ماندگاری می‌باشد، پژوهش سعی است اسپایک ویروس­‌ها به‌وسی...

Journal: :World Journal of Gastroenterology 2008

Journal: :Cancer research 2008
Jui-Hsiang Hung Yen-Shen Lu Yu-Chieh Wang Yi-Hui Ma Da-Sheng Wang Samuel K Kulp Natarajan Muthusamy John C Byrd Ann-Lii Cheng Ching-Shih Chen

This study was aimed at elucidating the mechanism by which FTY720, a synthetic sphingosine immunosuppressant, mediated antitumor effects in hepatocellular carcinoma (HCC) cells. The three HCC cell lines examined, Hep3B, Huh7, and PLC5, exhibited differential susceptibility to FTY720-mediated suppression of cell viability, with IC(50) values of 4.5, 6.3, and 11 mumol/L, respectively. Although FT...

2014
Takasuke Fukuhara Masami Wada Shota Nakamura Chikako Ono Mai Shiokawa Satomi Yamamoto Takashi Motomura Toru Okamoto Daisuke Okuzaki Masahiro Yamamoto Izumu Saito Takaji Wakita Kazuhiko Koike Yoshiharu Matsuura

Apolipoprotein B (ApoB) and ApoE have been shown to participate in the particle formation and the tissue tropism of hepatitis C virus (HCV), but their precise roles remain uncertain. Here we show that amphipathic α-helices in the apolipoproteins participate in the HCV particle formation by using zinc finger nucleases-mediated apolipoprotein B (ApoB) and/or ApoE gene knockout Huh7 cells. Althoug...

2018
Xiaoying Wang Jiefu Peng Jing Wang Miao Li Di Wu Songyan Wu Jipei Liao Jun Dou

Background Despite the breadth of understanding the noncoding RNAs' function in molecular biology, their functional roles in hepatocellular carcinoma (HCC) is poorly understood. In this study, we investigated the effect of hepatitis C virus (HCV) core upon the expression of noncoding RNAs. Methods The lncRNAs, mRNAs, and circRNAs were employed for identification of HCV core protein gene expre...

2017
Rong Gao Wei Gao Gang Xu Jie Xu Hao Ren

AIM To investigate the effect of a single amino acid mutation in human class B scavenger receptor I (SR-BI) on the infectivity of cell culture-derived hepatitis C virus (HCVcc) in SR-BI knock-down Huh7-siSR-BI cells. METHODS Site-directed mutagenesis was used to construct the SR-BI S112F mutation, and the mutation was confirmed by nucleotide sequencing. SR-BI knock-down Huh7-siSR-BI cells wer...

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