DNA topoisomerase II-an essential nuclear enzyme in DNA replication and transcription, chromatin segregation, and cell cycle progression-is also a target of clinically useful anticancer drugs. Preliminary observations of a positive correlation between the expression of topoisomerase (topo) IIalpha and the retinoblastoma protein (Rb) in a series of rhabdomyosarcoma cells prompted us to ask wheth...

The tumor suppressor Rb and the NuRD (nucleosome remodeling and histone deacetylation) complex have been implicated in transcriptional repression during cell cycle progression and cell fate specification. The Rb/E2F complex physically interacts with and thus recruits the NuRD complex to actively repress transcription. Caenorhabditis elegans counterparts of Rb, E2F/DP, and some NuRD complex comp...

For $A,Bin M_{nm},$ we say that $A$ is left matrix majorized (resp. left matrix submajorized) by $B$ and write $Aprec_{ell}B$ (resp. $Aprec_{ell s}B$), if $A=RB$ for some $ntimes n$ row stochastic (resp. row substochastic) matrix $R.$ Moreover, we define the relation $sim_{ell s} $ on $M_{nm}$ as follows: $Asim_{ell s} B$ if $Aprec_{ell s} Bprec_{ell s} A.$ This paper characterizes all linear p...

The sensitivities and specificities of 17 antibody detection tests for brucellosis in goats were estimated. Tests evaluated included the U.S. Department of Agriculture (USDA) card test with 8% cell concentration (8%Card), USDA rapid automated presumptive test (RAP), Mexican rose bengal plate tests with 8 and 3% cell concentrations (8%RB and 3%RB), French rose bengal plate test with 4.5% cell co...

In three experiments using Pavlovian conditioning of magazine approach, rats were trained with a compound stimulus, AB, and were concurrently trained with stimulus B on its own. The reinforcement rate of B, rB, was either 1/2, 2/3, or 2/5 of rAB. After extended training, the conditioning strength of A was assessed using probe trials in which A was presented alone. Responding during A was compar...

MicroRNA-155 (miR-155) plays pleiotropic roles in the biology of normal and malignant B lymphocytes, including the modulation of the transforming growth factor β (TGF-β) pathway via the targeting of SMAD5. However, the extent of the miR-155-mediated disruption of the TGF-β1/SMAD5 axis remains to be elucidated. To address this issue, we used the miR-155 knockout (KO) mouse and diffuse large B-ce...

The acid-base behavior of rhodamine B (RB) in reversed micellar solutions of cetyltrimethylammonium chloride (CTAC) in 1-hexanol-cyclohexane/water was investigated through absorption and fluorescence measurements under varying the hydrogen-ion concentration in a water pool, the mole fraction of 1-hexanol in a bulk solvent and the water to surfactant molar concentration ratio. RB exhibited equil...

The energy drink Red Bull (RB) has recently been shown to elevate resting blood pressure (BP) and double product (reflecting increased myocardial load). However, the extent to which these effects can be explained by the drink's caffeine and sugar content remains to be determined. We compared the cardiovascular impact of RB to those of a comparable amount of caffeine, and its sugar-free version ...

A data warehouse typically differs from an OLTP database in terms of both significantly larger sizes for data pages as well as in the volume of data inserted in bulk. The traditional B+ Tree and its variants, while still a popular candidate for supporting point and range queries, can become very memory intensive for insert and delete operations under these more stringent requirements. Since typ...