Pure acoustic neural models, particularly the LSTM-RNN model, have shown great potential in language identification (LID). However, the phonetic information has been largely overlooked by most of existing neural LID models, although this information has been used in the conventional phonetic LID systems with a great success. We present a phone-aware neural LID architecture, which is a deep LSTM...

Levodopa is the most effective therapy for the motor deficits of Parkinson's disease (PD), but long term treatment leads to the development of L-DOPA-induced dyskinesia (LID). Our previous studies indicate enhanced excitability of striatal cholinergic interneurons (ChIs) in mice expressing LID and reduction of LID when ChIs are selectively ablated. Recent gene expression analysis indicates that...

During prophase of the first meiotic division (prophase I), chromatin dynamically reorganises to recombine and prepare for chromosome segregation. Histone modifying enzymes are major regulators of chromatin structure, but our knowledge of their roles in prophase I is still limited. Here we report on crucial roles of Kdm5/Lid, one of two histone demethylases in Drosophila that remove one of the ...

Degeneration of dopaminergic neurons causes Parkinson's disease. Dopamine replacement therapy with L-DOPA is the best available treatment. However, patients develop L-DOPA-induced dyskinesia (LID). In the hemiparkinsonian rat, chronic L-DOPA increases rotations and abnormal involuntary movements modeling LID, via supersensitive dopamine receptors. Dopamine receptors are controlled by G protein-...

BACKGROUND Defects caused by excision of benign lid margin tumors are conventionally repaired by reconstructive surgery. However, second intention healing is another option for managing wounds on the lid margin. OBJECTIVE To evaluate the effectiveness of second intention healing after a shave excision of benign tumors on the lid margin. METHODS Lid defects following a shave excision of the ...

FOREWORD One of the most exciting new trends in water quality management today is the movement by many cities, counties, states, and private-sector developers toward the increased use of Low Impact Development (LID) to help protect and restore water quality. LID comprises a set of approaches and practices that are designed to reduce runoff of water and pollutants from the site at which they are...

Parkinson’s disease (PD) is a neurodegenerative movement disorder characterised by the motor features of tremor, rigidity and bradykinesia. These features are associated with the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta and a subsequent deficiency in striatal DA, which is required for the effective control of movements. However, there is evidence of a more diffuse...

Pancreatic triglyceride lipase (PTL) and the homologous pancreatic lipase related protein 2 (PLRP2) provide a unique opportunity to understand the molecular mechanism of lipolysis. They differ in substrate specificity, sensitivity to bile salts, and colipase dependence despite their close amino acid and tertiary structure identity. One important structure, present in both lipases, is the lid wh...

Numerous biomolecular interactions involve unstructured protein regions, but how to exploit such interactions to enhance the affinity of a lead molecule in the context of rational drug design remains uncertain. Here clarification was sought for cases where interactions of different ligands with the same disordered protein region yield qualitatively different results. Specifically, conformationa...