Selenium-dependent glutathione peroxidase-1 (GPX1) protects against reactive-oxygen-species (ROS)-induced oxidative stress in vivo, but its role in coping with reactive nitrogen species (RNS) is unclear. Our objective was to compare the protection of GPX1 against cytotoxicity of superoxide generator diquat (DQ), NO donor S-nitroso-N-acetyl-penicillamine (SNAP) and peroxynitrite generator 3-morp...

We compared the effects of DQ-113, a new quinolone, to those of vancomycin (VCM) and teicoplanin (TEIC) in murine models of hematogenous pulmonary infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and VCM-insensitive S. aureus (VISA). The MICs of DQ-113, VCM, and TEIC for MRSA were 0.125, 1.0, and 0.5 microg/ml, respectively; and those for VISA were 0.25, 8.0, and 8.0 micr...

Polymorphisms within HLA gene loci are strongly associated with susceptibility to autoimmune disorders; however, it is not clear how genetic variations in these loci confer a disease risk. Here, we devised a cell-surface MHC expression assay to detect allelic differences in the intrinsic stability of HLA-DQ proteins. We found extreme variation in cell-surface MHC density among HLA-DQ alleles, i...

In the human there are three isotypic forms of MHC class II gene products (HLA-DR, -DQ, and -DP). The isotype-matched alpha-beta dimers are predominant but isotype-mismatched dimers can also be expressed (DR alpha-DQ beta). Here it is shown that the expression of the DR alpha-DQ beta dimer can be correlated to a high ratio of DR alpha/DR beta mRNA. The DR alpha chain expression was modulated by...

18 transfected cell lines were generated that expressed distinct DQ molecules related to the serologically defined HLA-DQw3 specificity. These transfectants were constructed using site-directed mutagenesis to introduce nucleotide substitutions into DQ3.2 beta cDNA, followed by retrovirus-mediated gene expression of the mutagenized genes in human B cell lines with different endogenous DQ alpha c...

Abstract A Josephson quantum filter (JQF) protects a data qubit (DQ) from the radiative decay into transmission lines (TLs) in superconducting computing architectures. transmon, which is weakly nonlinear harmonic oscillator rather than pure two-level system, can play role of JQF or DQ. However, previous study, and DQ were modeled as systems neglecting effects higher levels. We theoretically exa...

OBJECTIVE To determine the sensitivity and specificity of postmortem dementia diagnoses based on a retrospective informant interview by comparison with criterion standard neuropathological diagnoses and the results of previous clinical examinations. SETTING Three university-based academic research centers. SUBJECTS Fifty-four deceased elderly persons with Alzheimer disease, another dementin...

Let N = pq be the product of two large primes. Consider CRT-RSA with the public encryption exponent e and private decryption exponents dp, dq. It is well known that given any one of dp or dq (or both) one can factorize N in probabilistic poly(logN) time with success probability almost equal to 1. Though this serves all the practical purposes, from theoretical point of view, this is not a determ...

Data Quality (DQ) has been an acknowledged issue for a long time, however research efforts in data quality has recently gained impetus. Several researches have indicated that maintaining the quality of data is often acknowledged as problematic, but is also seen as critical to effective decision-making in engineering asset management (AM). This paper aims to identify the need for developing an A...

The aim of this proceeding is to give a basic introduction to Deformation Quantization (DQ) to physicists. We compare DQ to canonical quantization and path integral methods. It is described how certain issues such as the roles of associativity, covariance, dynamics, and operator orderings are understood in the context of DQ. Convergence issues in DQ are mentioned. Additionally, we formulate the...