Sulfur mustard (SM) is a blistering agent that produces DNA strand breaks. To detect SM-induced DNA single strand breaks in human peripheral blood lymphocytes (PBL), cells were exposed to various concentrations of SM (10 to 1000 muM), and the comet assay (single-cell gel electrophoresis) was performed. We observed a SM concentration- and time-dependent increase in detectable DNA damage. To test...

background and objective: temporal lobe epilepsy is hallmarked with neuronal degeneration in some areas of hippocampus and mossy fiber sprouting in dentate area. considering some evidences on neuroprotective and antioxidant activity of silymarin (sm), this study was undertaken to evaluate the preventive effect of this agent on structural changes in hippocampus of kainate-epileptic rats. materia...

sulfur mustard (sm) has been identified as an important chemical weapon. during the iran-iraq war of 1980-88, the extensive usage of sm against iranian civilians and military forces was proven. this agent has been shown to cause severe damage mainly in the skin, eyes, lungs,  and  respiratory  tract  in  iranian  veterans.  the  most  common  disease  is bronchiolitis obliterans (bo)). sm incre...

BACKGROUND Both Schistosoma mansoni and Schistosoma haematobium cause schistosomiasis in sub-Saharan Africa. We assessed the diagnostic value of selected Schistosoma antigens for the development of a multiplex serological immunoassay for sero-epidemiological surveillance. METHODOLOGY/PRINCIPAL FINDINGS Diagnostic ability of recombinant antigens from S. mansoni and S. haematobium was assessed ...

background: sulfur mustard (sm) has acute and chronic effects on skin and mucosal surfaces. the aim of the study was to evaluate the frequency of esophagitis in a historical cohort of veterans who had been exposed to sm in iran-iraq war nearly 25 years ago.   methods : one hundred two veterans with dyspepsia and/or heartburn underwent esophago-gastro-duodenoscopy. of them, 52 cases had been exp...

sulphur mustard (sm) is an alkylating agent that was first used as a chemical warfare agent during the first world war in 1917. sm is readily absorbed from the skin, respiratory and gastrointestinal tract and is distributed to several organs. sm may act rapidly and persistently upon dna replicating mechanism of the individual cells during mitosis particularly in the hematopoietic system. of 233...

Introduction: Porphyrins are interesting derivatives with low toxicity, tumor avidity and rapid wash-out suggested as potential radiopharmaceuticals in radiolabeled form. In this work we report, synthesis, radiolabeling, quality control, stability, partition coefficient determination and biodistribution studies of 153Sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin (153Sm-4-MPP) in ...

A new type of gauge extension of the SM is proposed. It is based on a SU (2) × SU (2) × U (1) group with the peculiarity that the gauge bosons of the extra SU (2) do not couple to fermions. This feature relaxes some of the constraints on the masses of the new gauge bosons, leaving the possibility of having lighter masses than in traditional extensions. The model exhibits several interesting pro...

Studies of conformational changes of tRNA de­ pending on the ionic strength of the solution and the nature of the counter ions have become a subject of interest because of the probable role of its different conformational states for the functioning of the tRNA molecule in protein biosynthesis [1]. Results in this field obtained recently e.g. by pulsed nano­ second fluorometry [2] and laser ligh...