Tegafur (FT) is a prodrug of 5-fluorouracil (5-FU) used in cancer chemotherapy, and the bioactivation of FT to 5-FU is mainly catalyzed by cytochrome P450 (CYP) in hepatic microsomes. FT has a chiral center and is a racemate consisting of the enantiomers, R- and S-FT. In the present study, we clarified the enantioselectivity in the conversion of FT to 5-FU and identified human CYP isoforms invo...

Ferritin (Ft) plays an important role in cellular iron metabolism. It can store substantial amounts of iron in a nontoxic soluble form. However, its ability to donate iron for cellular needs, in particular for hemoglobin (Hb) synthesis in human erythroid cells, is still controversial. We studied the role of intracellular Ft-iron in Hb synthesis and the involvement of lysosomal proteolysis in ir...

We studied the effects of 5-ethynyluracil (776C85 and 776C), a potent mechanism-based inactivator of dihydropyrimidine dehydrogenase, on the antitumor efficacy and pharmacokinetics of tegafur (FT), a prodrug of 5-fluorouracil (5-FU), in rats with large s.c. colon carcinoma. Rats were dosed p.o. once daily for 7 days with either FT, FT and uracil in a 1:4 molar ratio (UFT), FT 1 h after 776C (77...

this research is aimed to undertake a comparative study on stability and thermal degradation kinetics of un-irradiated and high energy protons irradiated polyvinyl butyral (pvb) based on weight loss analysis and non-isothermal approaches. the weight loss by the un-irradiated pvb upon heating was found to be in two stages but due to high energy protons accelerated exposure following by chemical ...

background: n-acyl homoserine lactone (ahl) is found to be the main component of quorum sensing (qs) in gram-negative bacteria and plays an important role in biofilm formation. little information is available regarding the role of ahl in biofilm formation in escherichia coli (e. coli). the purpose of this investigation was to biochemically detect and characterize ahl activity in biofilm-forming...

مقاله‌ی حاضر با خوانشی انتقادی از رمان «مرد درحال سقوط» اثر دان دلیلو به واکاوی نقش هنرمند در ارائه‌ی مقاومت سیاسی برابر روایت وحشت برآمده رسانه‌های گروهی پس حوادث تروریستی یازدهم سپتامبر می‌پردازد. اسلوب و رویکرد ادبی این مقاله بر پایه‌ی‌ نظریات نظریه‌پرداز شهیر معاصر ژان بودریار است. پرسش‌هایی که پژوهش پیش‌رو مطرح می‌سازد است چگونه رویکردی جوامع نظام سرمایه‌داری ایفا می‌نمایند آیا قادر ضد می‌...