Over-the-counter (OTC) cough and cold medications are marketed widely for relief of common cold symptoms, and yet studies have failed to demonstrate a benefit of these medications for young children. In addition, OTC medications can be associated with significant morbidity and even mortality in both acute overdoses and when administered in correct doses for chronic periods of time. Physicians o...

Oxytetracycline (OTC) significantly inhibited cytochrome c oxidase activity in bovine lymphocytes infected with Theileria parva and in uninfected mitogen-stimulated lymphocytes. The inhibitory effect was detected in vitro within 24 h of treatment with drug concentrations as low as 1 micrograms/ml. Following mitogen stimulation of lymphocytes, concentrations of 3 and 10 micrograms/ml OTC complet...

OBJECTIVE To evaluate the financial effects in a state employee health plan of a change in the drug coverage policy to include over-the-counter (OTC) omeprazole in a tier-copayment drug benefit design that favored the OTC drug. METHODS The policy change in the Arkansas State Employee Benefit Division (EBD) involved 2 principal parts: OTC omeprazole placed in a new OTC copayment tier (5 dollar...

L-2-oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrug that maintains glutathione in tissues. Here, its effect on alcohol-induced liver injury in an enteral alcohol feeding model was investigated. Male Wistar rats were given control high-fat or ethanol containing diets enterally for 4 weeks. Treated rats received 500 mg/kg/d of dietary OTC. Ethanol delivery, weight gain, and the cycl...

Effects of pH on adsorption and removal efficiency of ionizable organic compounds (IOCs) by environmental adsorbents are an area of debate, because of its dual mediation towards adsorbents and adsorbate. Here, we probe the pH-dependent adsorption of ionizable antibiotic oxytetracycline (comprising OTCH2 (+), OTCH(±), OTC(-), and OTC(2-)) onto cyclodextrin polymers (CDPs) with the nature of mole...

Since 2005, California law allowed over-the-counter (OTC) syringe sales pending local authorization. Although pharmacy sales of OTC syringes are associated with reduced injection-mediated risks and decreases in human immunodeficiency virus infection rates, little is known about the factors associated with syringe purchase among injection drug users (IDUs). Using a cross-sectional design, the au...

Self-medication with over-the-counter (OTC) drugs is an economical choice of treatment for common self-limiting illnesses. As more medications are made available as OTC drugs, and as the population of older adults continues to increase, a need arises to monitor how elderly individuals use these agents. The purpose of this study was to assess the self-medication practices with OTC drugs among ol...

determination of drug residues in food is of great importance due to their toxicity. long-term exposure with low level of drug residues could be important, especially in children. based on document study, oxytetracycline (otc) is a prophylaxis and treatment agent for great number of diseases and possesses a broad spectrum activity against many pathogenic organisms and can be toxic or cause alle...

Sable®sh (Anoplopoma ®mbria) were recaptured up to 20 years after being injected with oxytetracycline (OTC). After 20 years the OTC mark is clear in most otoliths. Our examination of these otoliths con®rmed that sable®sh are long-lived and grow slowly after maturity. Annuli that formed beyond the OTC mark could be dif®cult to interpret in broken and burnt sections. However, polished thin sectio...

BACKGROUND Worldwide Ministries of Health (MoH) are encouraged to publish an updated Over-the-Counter (OTC)-Directory that pharmacists should adhere to in dispensing non-prescription medications. The Saudi Ministry of Health has published the OTC-Directory in the year 2000, and since then, it was readily available to all practicing pharmacists at no cost. This study was aimed to investigate the...