In many-core CMP architectures, the cache coherence protocol is a key component since it can add requirements of area and power consumption to the final design and, therefore, it could restrict severely its scalability. Area constraints limit the use of precise sharing codes to smallor medium-scale CMPs. Power constraints make impractical to use broadcast-based protocols for large-scale CMPs. T...

Human immunodeficiency virus (HIV) infection has been associated with cardiac disease, including anatomical or functional disturbance to the heart. Cardiomyopathy (CMP) is one of these disturbances that have been associated with high rates of morbidity and mortality. In this review article, several aspects of potential relationships between HIV infection and cardiomyopathy development have been...

Human UMP/CMP kinase (cytidylate kinase; EC 2.7.4.14) is responsible for phosphorylation of CMP, UMP, and deoxycytidine monophosphate (dCMP) and also plays an important role in the activation of pyrimidine analogs, some of which are clinically useful anticancer or antiviral drugs. Previous kinetic data using recombinant or highly purified human UMP/CMP kinase showed that dCMP, as well as pyrimi...

SpĂĄnkovĂŠ poruchy dĂ˝chania predstavujĂş vĂ˝znamnĂ˝ rizikovĂ˝ faktor cerebrovaskulĂĄrnych ochorenĂ­. SyndrĂłm spĂĄnkovĂŠho apnoe (SAS) je u pacientov s cievnou mozgovou prĂ­hodou (CMP) častĂ˝ a nepriaznivo ovplyvňuje ich zdravotnĂ˝ stav. Napriek tomu ostĂĄva veÄžkĂĄ časĹĽ CMP po tejto strĂĄnke nediagnostikovanĂ˝ch prichĂĄdza o potenciĂĄlny benefit pretlakovej ventilačnej liečby. V tomto Ä...

Chemical mechanical polishing (CMP) is an essential planarization process for semiconductor manufacturing. The application of CMP has been increasing in fabrication highly integrated devices. Recently, environmental burden caused by the was assessed because interest global environment. In this study, previously reported impacts on environment and studies conducted developing various methods to ...

Phosphorylation of deoxycytidine analogs by cellular enzymes is a prerequisite for the activity of these compounds. We have investigated the kinetic parameters for the phosphorylation of 1-beta-D-arabinofuranosylcytosine (araC) and 2', 2'-difluorodeoxycytidine (dFdC) to their diphosphate forms catalyzed by human UMP-CMP kinase. We cloned the cDNA of this enzyme to enable characterization of the...

Pyrimidine nucleoside monophosphate kinase [UMP/CMP kinase (UMP/CMPK);EC 2.7.4.14] plays a crucial role in the formation of UDP, CDP, and dCDP, which are required for cellular nucleic acid synthesis. Several cytidine and deoxycytidine analogues are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to their triphosphate forms to exert their therapeutic effect...