Periodic centroidal Voronoi tessellation (CVT) in hyperbolic space provides a nice theoretical framework for computing the constrained CVT on high-genus (genus > 1) surfaces. This paper addresses two computational issues related to such hyperbolic CVT framework: (1) efficient reduction of unnecessary site copies in neighbor domains on the universal covering space, based on two special rules; (2...

The cytoplasm-to-vacuole targeting (Cvt) pathway of Saccharomyces cerevisiae delivers aminopeptidase I (Ape1) from the cytosol to the vacuole, bypassing the normal secretory route. The Cvt pathway, although well-studied, was known only in S. cerevisiae. We demonstrate its existence in the methylotrophic yeast, Pichia pastoris, where it also delivers P. pastoris Ape1 (PpApe1) to the vacuole. Mos...

PURPOSE To explore the effectiveness of canine visitation therapy (CVT) in pediatric pain management in a tertiary care children's hospital, a descriptive pilot study was conducted. METHOD A convenience sample of 25 English-speaking children ages 5 to 18 years who underwent surgery and experienced acute postoperative pain participated in a standard, one-time CVT intervention. Each child compl...

The centroidal Voronoi tessellation (CVT) has found versatile applications in geometric modeling, computer graphics, and visualization, etc. In this paper, we first extend the concept of CVT from Euclidean space to spherical space and hyperbolic space, and then combine all of them into a unified framework – the CVT in universal covering space. The novel spherical and hyperbolic CVT energy funct...

Several potent and selective A2A adenosine receptor agonists are currently available. These compounds have a high affinity for the A2A receptor and a long duration of action. However, in situations where a short duration of action is desired, currently available A2A receptor agonists are less than ideal. From a series of recently synthesized A2A receptor agonists, two agonists (CVT-3146 and CVT...

‘Non-excludability’ of skills is suspected to give rise to poaching externalities and cause under-investment in training. To substantiate this hypothesis, the paper at hand investigates the relationship between labor turnover and firms’ dedication to continuing vocational training (CVT) exploiting novel survey data on firms in Germany (BIBB-FluCT data, N = 1.238). Regression analyses of these d...

CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium) showed immunomodulating activity. Cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT), and glutathione S-transferase (GST) are important drug-metabolizing enzymes. Modulation of drugmetabolizing enzymes is a main cause of drug interactions. To assess the possible metabolism-based drug interaction of CVT-E002...

This article reports on the design, analysis and control of a new type of wheeled mobile robot based on a nonholonomic spherical continuously variable transmission (S-CVT). Our S-CVT based mobile robot is designed to increase the run time (i.e., the length of time in which the robot can be operated), and to achieve full planar accessibility with the design of a novel pivoting device that takes ...