We describe the genetic and kinetic defects for a low-affinity fast channel disease of the acetylcholine receptor (AChR) that causes a myasthenic syndrome. In two unrelated patients with very small miniature end plate (EP) potentials, but with normal EP AChR density and normal EP ultrastructure, patch-clamp studies demonstrated infrequent AChR channel events, diminished channel reopenings durin...

background and objectives: clostridium perfringens, a gram-positive obligate anaerobic bacterium, is able to form resistant spores which are widely distributed in the environment. c. perfringens is subdivided into five types a to e based on its four major alpha, beta, epsilon and iota toxins. the aim of the present study was cloning and expression of c. perfringens type d vaccine strain epsilon...

The Fc region of immunoglobulin E (IgE) comprising the C epsilon 3 and C epsilon 4 domains (residues 329-547) is sufficient for binding to the high-affinity IgE Fc receptor (Fc epsilon RI alpha). Three potential N-linked glycosylation sites are present within the C epsilon 3 domain. To determine the effect of the glycosylation sites on IgE Fc synthesis and on Fc epsilon RI alpha binding, site-d...

In this paper we consider an exactly solvable model that displays glassy behavior at zero temperature due to entropic barriers. The new ingredient of the model is the existence of different energy scales or modes associated with different relaxational time scales. Low-temperature relaxation takes place by partial equilibration of successive lower-energy modes. An adiabatic scaling solution, def...

A new in vivo method was used to determine an average volumetric elastic modulus ([epsilon]ave) for nongrowing cells in plant tissue. This method requires that both the relative transpiration rate, T, of the tissue and the average turgor pressure decay rate, (dP/dt)ave, of the cells are measured after the water source is removed from the plant tissue. Then [epsilon]ave is calculated from the eq...

We analyzed blood samples from 407 healthy Swedish individuals, 244 men and 163 women, ages 17 to 86 years, for apolipoprotein (apo) E isoforms and serum triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol. Parallel genotyping by means of polymerase chain reaction (PCR)-amplified DNA was performed in 200 subjects. Identical results were obtained b...

For any $\epsilon>0$, Laue and Matijevic [CCCG'07, IPL'08] give a PTAS for finding $(1+\epsilon)$-approximate solution to the $k$-hop MST problem in Euclidean plane that runs time $(n/\epsilon)^{O(k/\epsilon)}$. In this paper, we present an algorithm $(n/\epsilon)^{O(\log k \cdot(1/\epsilon)^2\cdot\log^2(1/\epsilon))}$. This gives improvement on dependency $k$ exponent, while having worse $\eps...

BACKGROUND Epsilon-aminocaproic acid (epsilon-ACA), an antifibrinolytic agent, is used in cardiac surgery to decrease postoperative bleeding. Theoretical concerns exist about the potential for epsilon-ACA to contribute to thrombotic complications. For this reason epsilon-ACA administration is sometimes delayed until after heparinization. This study investigated the impact of the timing of epsil...

Non-invasive strategies for the analysis of endogenous DNA damage are of interest for the purpose of monitoring genomic exposure to biologically produced chemicals. We have focused our research on the biological processing of DNA adducts and how this may impact the observed products in biological matrixes. Preliminary research has revealed that pyrimidopurinone DNA adducts are subject to enzyma...

The behavior of the positron- 2 gamma annihilation rate on an atomic target near the positronium (Ps) formation threshold is determined. When the positron energy epsilon approaches the threshold epsilon(thr) from below, the effective number of electrons contributing to the annihilation, Z(eff), grows as Z(eff) approximately A/square root of [epsilon(thr)-epsilon], where A is related to the size...