Manganese peroxidases (MnPs) are interesting enzymes in protein engineering, aimed at maximizing industrial bioprocesses such as lignin degradation and biofuel production. cDNA of the secreted shorttype of MnP from Phlebia radiata (Pr-MnP3) has been successfully engineered and amplified by polymerase chain reaction (PCR). Five mutant genes (E40H, E44H, E40H/E44H, D186H and D186N) of recombinant...

Compounds can activate human ether-à-go-go-related gene 1 (hERG1) channels by several different mechanisms, including a slowing of deactivation, an increase in single channel open probability, or a reduction in C-type inactivation. The first hERG1 activator to be discovered, RPR260243 ((3R,4R)-4-[3-(6-methoxyquinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluorophenyl)-prop-2-ynyl]-piperidine-3-car...

A fast and switchable electro-optic radial polarization retarder (EO-RPR) fabricated using the electro-optic ceramic Pb(Mg(1/3)Nb(2/3))O(3)-PbTiO(3) is presented. This EO-RPR is useful for fast and switchable generation of a pure cylindrical vector beam. When used together with a pair of half-wave plates, the EO-RPR can change circularly polarized light into any cylindrical vector beam of inter...

In a prior study, we reported that a high proportion of hens in a winter-laying flock became relatively photorefractory (rPR) early in the reproductive cyand that successive short-term reductions in photoperiod in such hens each initially depressed egg production but then caused a rebound in rate of lay to briefly exceed that of hens that did not exhibit rPR. The present study was conducted to ...

The steroid hormone ecdysone directs the massive destruction of obsolete larval tissues during Drosophila metamorphosis, providing a model system for defining the molecular mechanisms of steroid-regulated programmed cell death. Although earlier studies have identified an ecdysone triggered genetic cascade that immediately precedes larval tissue cell death, no death regulatory genes have been fu...

Haematological indices, including neutrophil-lymphocyte ratio (NLR), red blood cell distribution width (RDW), and red blood cell distribution width-platelet ratio (RPR) are used to assess the severity of various diseases. We aim to evaluate the relationship between these parameters and the severity of Hepatitis B Virus (HBV) related cirrhosis. The study consisted of 78 patients with HBV-related...

Reverse sequence screening for syphilis (RSSS) (screening with treponemal tests, followed by confirmation with nontreponemal tests) has been increasingly adopted. CDC recommends confirmation of discordant results (reactive EIA/CIA and nonreactive nontreponemal test) with Treponema pallidum particle agglutination assay (TP-PA). We characterized sera with discordant results from RSSS with Archite...

Syphilis, which is caused by Treponema pallidum, is a chronic bacterial infection that remains a public health concern worldwide. Serologic testing is the method most often used, as the bacterium cannot be cultured. Syphilis serological tests are divided into nontreponemal and treponemal tests, and neither is sufficient alone for diagnosis, as each type of test has limitations, including the po...

Currently clinicians advice rotational panoramic radiography (RPR) for preliminary investigation. Despite few inherent limitations, rotational panoramic radiography still remains the diagnostic tool of choice. Abnormal structures such as a supernumerary tooth or a device falling within the certain central regions in conventional RPR images may mislead the clinicians towards an inaccurate diagno...

Activators of human ether-a-go-go-related gene 1 (hERG1) channels, such as (3R,4R)-4-[3-(6-methoxy-quinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl]-piperidine-3-carboxylic acid (RPR260243), reverse the effect of hERG1 blockers and shorten the duration of cardiac action potentials. RPR260243 (RPR) slows the rate of deactivation and shifts the voltage dependence of channel ...