BACKGROUND/AIMS Angiotensin II (AngII) type 1 receptor (AT1R) could be activated by mechanical stress without the involvement of AngII during the development of cardiac hypertrophy. We aimed to identify sensing sites of AT1R for activation by mechanical stretch. METHODS We constructed several site-directed mutations of AT1R (AT1R(K199Q), AT1R(L212F), AT1R(Q257A) and AT1R(C289A)), transfected ...

OBJECTIVE The aim of this study was to investigate the success rate and effects on survival of different anti-thymocyte globulin (ATG) preparations in patients diagnosed with aplastic anemia. SUBJECTS AND METHODS Of the total 24 patients included in the study, 12 were male and 12 female with a median age of 44 years (range 16-72). Nine patients received Lymphoglobulin®, 7 Thymoglobulin® and A...

Autophagy-related (ATG) proteins have increasingly demonstrated functions other than cellular self-eating. In this issue, Mauthe et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201602046) conduct an unbiased RNA interference screen of the ATG proteome to reveal numerous noncanonical roles for ATG proteins during viral infection.

The childhood bone marrow failure disorders are a heterogeneous group of diseases of which the commonest ones are acquired severe aplastic anemia (SAA) and myelodysplastic syndromes. SAA is characterized by the presence of pancytopenia with a hypocellular marrow in the absence of malignant infiltration or fibrosis. Myelodysplastic syndromes are characterized by ineffective hematopoiesis, dyplas...

Antithymocyte globulin (ATG) is used in the prevention of graft-versus-host disease during allogeneic hematopoietic stem cell transplantation. It is generally accepted that ATG mediates its immunosuppressive effect primarily via depletion of T cells. Here, we analyzed the impact of ATG-Fresenius (now Grafalon®) on human monocyte-derived dendritic cells (DC). ATG induced a semi-mature phenotype ...

سابقه و هدف: به ­دلیل توسعه رشد جمعیت انسان، نیاز انسان منابع ضروری افزایش یافته است. فعالیت‌های مربوط صنایع همچنین کشاورزی به­ طور گسترده‌ای زمین‌های را آلوده کرده ترکیبات نفتی فلزات سنگین هر دو از آلاینده‌های رایج موجود در خاک‌هایی هستند که با فاضلاب تصفیه نشده آبیاری شده‌اند سلامت محیط زیست خطر مواجه می‌کنند. آلودگی خاک می‌تواند سبب کاهش امکان زراعت، نهایت تولید غذا برای شود. جنوب شهر تهران ...

Severe aplastic anemia (SAA) is a rare disorder leading to bone marrow failure, which if left untreated, is invariably fatal. Conventional therapies with immunosuppressive therapy or allogeneic hematopoietic stem cell transplantation (HSCT) are highly effective. HSCT can offer a greater outcome in younger patients who have an available HLA match-related donor. Recent studies showing the additio...

Oligonucleotides designed to create hairpin structures were inserted upstream from the ATG initiator codon in several plasmids that encode preproinsulin, and the effects on translation were monitored in COS cells transfected by the vectors. Creation of a hairpin (delta G = -30 kcal/mol) that directly involves the ATG triplet at the start of the preproinsulin coding sequence does not reduce the ...