MAGE genes encode tumor-specific shared antigens that are among the most interesting candidates for cancer vaccines. Despite extensive studies, however, CD8+ T-cell responses to MAGE-derived epitopes have been detected only occasionally in cancer patients, even after vaccination. In contrast with these findings, we report here that HLA-A2 melanoma patients respond frequently to the recently ide...

We generalise the previously given E11 half BPS solution generating group element to general weights of A10. We find that it leads to solutions of M The signature transformations of the solution are naturally generated by the Weyl reflections required to transform the lowest A10 weight into a general weight in the same representation. We also rediscover known S-brane solutions in M-theory from ...

Peptide dendrimers consist of a peptidyl branching core and/or covalently attached surface functional units. They show a variety of biological properties, including antiviral activity. In this study, a minilibrary of linear, dimeric, and dendrimeric peptides containing clusters of basic amino acids was evaluated for in vitro activity against human papillomaviruses (HPVs). The peptide dendrimer ...

We generalise the previously given E11 half BPS solution generating group element to general weights of A10. We find that it leads to solutions of M The signature transformations of the solution are naturally generated by the Weyl reflections required to transform the lowest A10 weight into a general weight in the same representation. We also rediscover known S-brane solutions in M-theory from ...

This data article contains data related to the research article entitled "Rapid detection of enterovirus and Coxsackievirus A10 by a TaqMan based duplex one-step real time RT-PCR assay" (Chen at al., 2017) [1]. Primers and probe sequence design are among the most critical factors in real-time polymerase chain reaction (PCR) assay optimization. Linearity, sensitivity, specificity and precision a...

Microsatellite instability is a key mechanism of colon carcinogenesis. We have previously studied mutations within a (CA)13 microsatellite using an enhanced green fluorescent protein (EGFP)-based reporter assay that allows the distinction of replication errors and mismatch repair (MMR) activity. Here we utilize this assay to compare mutations of mono- and dinucleotide repeats in human colorecta...

BACKGROUND The early detection of coagulopathy helps guide decisions regarding optimal transfusion management during cardiac surgery. This study aimed to determine whether rotational thromboelastometry (ROTEM) analysis during cardiopulmonary bypass (CPB) could predict thrombocytopenia and hypofibrinogenemia after CPB. METHODS We analyzed 138 cardiac surgical patients for whom ROTEM tests and ...

s A1–A10 5 Basic Science – Genetics, Epigenetics, miRNAs