Idiopathic inflammatory myopathies (IIM) are a group of diseases characterized by muscle weakness, which limit activities daily living. Patient Reported Outcomes Measurement Information System (PROMIS) is set outcome measures developed using NIH funding, but has not yet been studied in adult IIM. Currently, the most commonly used PROs IIM Health Assessment Questionnaire (HAQ-DI) and SF-36 physi...

Planning systems are typically told what goals to pursue and cannot modify them. Some methods (e.g., for contingency planning, dynamic replanning) can respond to execution failures, but usually ignore opportunities and do not reason about the goals themselves. Goal-Driven Autonomy (GDA) relaxes some common assumptions of classical planning (e.g., static environments, fixed goals, no unpredictab...

To operate autonomously in complex environments, agents must perform actions, sense the environment, and respond to new situations. Traditional approaches face difficulties with incomplete environment models, goal specification, and engineering domain specific control knowledge. We believe goal reasoning will address these challenges enabling agents to better respond to unexpected circumstances...

Unmanned vehicles have been the focus of active research on autonomous motion planning, both deliberative and reactive. However, they are fundamentally limited in their autonomy by an inability to independently reason about, prioritize, and change the goals they pursue. We describe two new projects in which we are incorporating goal autonomy on unmanned vehicle platforms. We will apply the Goal...

Human Activity Recognition (HAR) from time-sequential video images is an active research area in various applications such as video surveillance and smart homes nowadays. This paper presents a novel approach of automatic HAR based on Generalized Discriminant Analysis (GDA) on Enhanced Independent Component (EIC) features from binary silhouette information to be used with Hidden Markov Model (HM...

Several Hsp90 modulators have been identified including the N-terminal ligand geldanamycin (GDA), the C-terminal ligand novobiocin (NB), and the co-chaperone disruptor celastrol. Other Hsp90 modulators elicit a mechanism of action that remains unknown. For example, the natural product gedunin and the synthetic anti-spermatogenic agent H2-gamendazole, recently identified Hsp90 modulators, manife...

Abstract Video summarization is an effective way to facilitate video searching and browsing. Most of existing systems employ encoder-decoder based recurrent neural networks, which fail explicitly diversify the system-generated summary frames while requiring intensive computations. In this paper, we propose efficient convolutional network architecture for SUMmarization via Global Diverse Attenti...

Glycodelin-A (GdA) is a member of the superfamily of lipocalins and the predominant glycoprotein secreted by human and primate endometrium in the secretory and early pregnancy phases. GdA can inhibit NK cell activity, T cell proliferation, and chemotaxis of monocytes. Its physiological function is thought to mediate immunotolerance at the fetomaternal interface. In the present studies, we engin...