As a latest immune algorithm, dendritic cell algorithm (DCA) has been successfully applied into the abnormal detection. First, this paper reviewed the research progress of DCA from the following aspects: signal extraction technology, DCA signal processing technology, the decision method for load anomaly judgment, and the application research of DCA. Next, the corresponding solving thoughts for ...

BACKGROUND Chronic hypoxic pulmonary hypertension (CH-PHT) is associated with suppressed expression and function of voltage-gated K(+) channels (Kv) in pulmonary artery (PA) smooth muscle cells (SMCs) and a shift in cellular redox balance toward a reduced state. We hypothesized that dichloroacetate (DCA), a metabolic modulator that can shift redox balance toward an oxidized state and increase K...

Both dichloroacetate (DCA) and metformin (Met) have shown promising antitumor efficacy by regulating cancer cell metabolism. However, the DCA-mediated protective autophagy and Met-induced lactate accumulation limit their tumor-killing potential respectively. So overcoming the corresponding shortages will improve their therapeutic effects. In the present study, we found that DCA and Met synergis...

Chloroform, dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are mouse liver carcinogens that are chlorine disinfection by-products found in drinking water. The effect of chloroform on DCA and TCA-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors was determined. B6C3F1 mice were administered 0, 400, 800 and 1600 mg/l chloroform in...

Pathways of metabolism of dichloroacetate (DCA), an investigational drug for the treatment of lactic acidosis in humans and a rodent hepatocarcinogen, are poorly understood. In this study, rats were given, by gavage, one or two 50 mg/kg doses of NaDCA. DCA labeled with 14C (carboxy carbon) or 13C (both carbons) was used in studies of disposition and pharmacokinetics, respectively. The effect of...

Dichloroacetate (DCA) is an inhibitor of pyruvate dehydrogenase kinase, which promotes the flux of carbohydrates into mitochondria and enhances the aerobic oxidation of glucose. DCA has previously been demonstrated to exhibit antitumor properties. The present study revealed that treatment with DCA induced increased levels of autophagy-associated proteins in esophageal squamous carcinoma cells w...

هدف از انجام این پژوهش ارائه الگوی برنامه کلان ملی شفافیت و آزادسازی اطلاعات می‌باشد. دارای رویکردی تلفیقی (کیفی کمی) بوده روش نظریه داده‌بنیاد (گراندد تئوری) به‌عنوان تحقیق استفاده شده است. در بخش کیفی با بررسی عمیق اکتشافی قوانین اسناد بالادستی، الگوها، نظریه‌ها، برنامه‌ها کشورهای مختلف مرتبط اطلاعات، تحلیل داده‌ها تا حد اشباع نظری، طی سه مرحله کدگذاری باز، محوری انتخابی گرفت. به‌منظور دستیاب...

هدف: با توجه به اهمیت سرمایه­‌های انسانی سازمان و ویژه استعدادها عنوان مهم­ترین ابزار کسب مزیت رقابتی، هدف از انجام این پژوهش ارائه مدلی برای مدیریت استعداد در صنعت خودرو است.طراحی/ روش‌شناسی/ رویکرد: پژوهش، صورت ترکیبی اکتشافی (کیفی-کمی) شده است. فاز کیفی، اجزای یک مدل روش تحلیل تم شناسایی شد. کمی، اجزاء روابط استخراج استفاده مدلسازی معادلات ساختاری، مورد ارزیابی قرار گرفت تا متغیرهای مرتبط ار...

A positive association between deoxcholic acid (DCA) in the serum and colorectal adenomas, the precursors of colorectal cancer has recently been found, which supported the hypothesis of a pathogenic role of DCA in colonic carcinogenesis. This approach was based on the hypothesis that DCA formed in the colon is absorbed into the portal venous blood and exhibits a constant spillover to the system...

The instructive structure-property relationships of ionic liquids (ILs) can be put to task-specific design of new functionalized ILs. The dicyanamide (DCA) ILs are typical CHN type ILs which are halogen free, chemical stable, low-viscous, and fuel-rich. The transport properties of DCA ionic liquids are significant for their applications as solvents, electrolytes, and hypergolic propellants. Thi...