Codeinone (3) was efficiently and directly converted to 14-hydroxycodeinone (1) by catalytic air oxidation in aqueous solution. A number of simple manganese and copper salts were identified to be effective catalysts, including MnSO4, KMnO4, and CuSO4. An appropriate reducing agent, such as sodium thiosulfate, is required in the reaction mixture presumably for the reduction of a detrimental pero...

Noroxymorphone is a pivotal intermediate in the synthesis of important opioid antagonists such as naloxone and naltrexone. The preparation noroxymorphone from thebaine, naturally occurring opioate isolated poppy extract, multistep sequence which oxycodone first generated then N- O-demethylated. Both demethylations are problematic safety sustainability viewpoint, they involve harmful reagents al...

In this research, a number of chemical compounds were estimated and identified in the crude extract both E. helioscopia peplus species, as it was noted that there about twenty alkaloid them, It was, also, three present species. had highest concentration alkaloids: Scopalamine, Colchicino theobromine. Presence following alkaloids observed Species helioscopia, namely; Metamfepramone, Phencyclidin...